Manganese Overexposure Alters Neurogranin Expression and Causes Behavioral Deficits in Larval Zebrafish.

Animals Zebrafish / metabolism Larva / drug effects Behavior, Animal / drug effects Neurogranin / metabolism Manganese / toxicity Chlorides / toxicity Manganese Compounds
Danio rerio development manganese neurogranin neurotoxicity

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Apr 2024
Historique:
received: 14 03 2024
revised: 22 04 2024
accepted: 26 04 2024
medline: 11 5 2024
pubmed: 11 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

Manganese (Mn), a cofactor for various enzyme classes, is an essential trace metal for all organisms. However, overexposure to Mn causes neurotoxicity. Here, we evaluated the effects of exposure to Mn chloride (MnCl

Identifiants

DOI: 10.3390/ijms25094933 PMID: 38732149
pubmed: 38732149
pii: ijms25094933
doi: 10.3390/ijms25094933
pii:
doi:

Substances chimiques

Neurogranin 132654-77-4
Manganese 42Z2K6ZL8P
manganese chloride QQE170PANO
Chlorides 0
Manganese Compounds 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/V006754/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 224113/Z/21/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 225445/Z/22/Z
Pays : United Kingdom

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Auteurs

Anabel Alba-González (A)

Department of Biology, Faculty of Sciences, University of A Coruña, 15008 A Coruña, Spain.
Centro Interdisciplinar de Química y Biología, (CICA), University of A Coruña, 15071 A Coruña, Spain.
ORCID: 0000-0003-1627-3006

Elena I Dragomir (EI)

Department of Cell and Developmental, University College London, London, WC1E 6BT, UK.
ORCID: 0000-0002-4189-7622

Golsana Haghdousti (G)

Department of Cell and Developmental, University College London, London, WC1E 6BT, UK.
ORCID: 0009-0004-4348-8525

Julián Yáñez (J)

Department of Biology, Faculty of Sciences, University of A Coruña, 15008 A Coruña, Spain.
Centro Interdisciplinar de Química y Biología, (CICA), University of A Coruña, 15071 A Coruña, Spain.
ORCID: 0000-0002-4559-8398

Chris Dadswell (C)

School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.

Ramón González-Méndez (R)

School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.
ORCID: 0000-0002-6481-456X

Stephen W Wilson (SW)

Department of Cell and Developmental, University College London, London, WC1E 6BT, UK.

Karin Tuschl (K)

UCL GOSH Institute of Child Health, University College London, London, WC1N 1EH, UK.
ORCID: 0000-0001-8599-8516

Mónica Folgueira (M)

Department of Biology, Faculty of Sciences, University of A Coruña, 15008 A Coruña, Spain.
Centro Interdisciplinar de Química y Biología, (CICA), University of A Coruña, 15071 A Coruña, Spain.
ORCID: 0000-0003-2927-7516

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Métamorphose biologique › Étapes du cycle de vie › Larve › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neurogranine › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Manganèse › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Manganese Overexposure Alters Neurogranin...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du manganèse › Manganese Overexposure Alters Neurogranin...