Hydrops fetalis caused by a complex congenital heart defect with concurrent hypoplasia of pulmonary blood vessels and lungs visualized by micro-CT in a French Bulldog.
Aortic arch interruption
Fetal anasarca
Hydrops fetalis
Transposition of great arteries
micro-CT
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
11 May 2024
11 May 2024
Historique:
received:
14
04
2023
accepted:
06
05
2024
medline:
12
5
2024
pubmed:
12
5
2024
entrez:
11
5
2024
Statut:
epublish
Résumé
Hydrops fetalis (HF) is fluid accumulation in fetus body cavities and subcutaneous tissue. The condition has been described in various farm and companion animal species, including dogs. Most of cases result from a heart defect. Exact nature of this defect is rarely clarified. A newborn, male French bulldog puppy with severe HF underwent a full anatomopathological examination to diagnose the primary cause of HF. Based on the anatomopathological examination, fetal ultrasound, and micro-computed tomography, transposition of the great arteries with hypoplasia of the ascending aorta, aortic arch interruption, ostium secundum atrial septal defect, severe tricuspid valve dysplasia, as well as hypoplasia of pulmonary vessels and lungs were diagnosed. This is the first report of HF caused by severe, complex congenital heart defects with concurrent pulmonary vessel and lung hypoplasia.
Sections du résumé
BACKGROUND
BACKGROUND
Hydrops fetalis (HF) is fluid accumulation in fetus body cavities and subcutaneous tissue. The condition has been described in various farm and companion animal species, including dogs. Most of cases result from a heart defect. Exact nature of this defect is rarely clarified.
CASE PRESENTATION
METHODS
A newborn, male French bulldog puppy with severe HF underwent a full anatomopathological examination to diagnose the primary cause of HF. Based on the anatomopathological examination, fetal ultrasound, and micro-computed tomography, transposition of the great arteries with hypoplasia of the ascending aorta, aortic arch interruption, ostium secundum atrial septal defect, severe tricuspid valve dysplasia, as well as hypoplasia of pulmonary vessels and lungs were diagnosed.
CONCLUSIONS
CONCLUSIONS
This is the first report of HF caused by severe, complex congenital heart defects with concurrent pulmonary vessel and lung hypoplasia.
Identifiants
pubmed: 38734649
doi: 10.1186/s12917-024-04060-5
pii: 10.1186/s12917-024-04060-5
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189Informations de copyright
© 2024. The Author(s).
Références
Having K, Bullock S. Fetal Anasarca. J Diagn Med Sonogr. 2011;27(1):19–25.
doi: 10.1177/8756479310392351
Bellini C, Hennekam RC. Non-immune hydrops fetalis: a short review of etiology and pathophysiology. Am J Med Genet. 2012;158A(3):597–605.
doi: 10.1002/ajmg.a.34438
pubmed: 22302731
Swearingen C, Colvin ZA, Leuthner SR. Nonimmune Hydrops Fetalis. Clin Perinatol. 2020;47(1):105–21.
doi: 10.1016/j.clp.2019.10.001
pubmed: 32000919
Alagar S, Velladurai C, Manivannan S, Selvaraju M. Succesfull Management of Dystocia due to Foetal Anasarca in Holstein Friesian crossbred cows. Theriogen Insi. 2017;7(3):205.
doi: 10.5958/2277-3371.2017.00039.0
Häfliger IM, Wiedemar N, Švara T, Starič J, Cociancich V, Šest K, et al. Identification of small and large genomic candidate variants in bovine pulmonary hypoplasia and anasarca syndrome. Anim Genet. 2020;51(3):382–90.
doi: 10.1111/age.12923
pubmed: 32069517
Monteagudo L, Luján L, Tejedor T, Climent S, Acı́n C, Navarro A, et al. Fetal anasarca (hydrops foetalis) associated with lymphoid tissue agenesis possibly due to an autosomal recessive gene defect in sheep. Theriogenology. 2002;58(6):1219–28.
doi: 10.1016/S0093-691X(02)00945-7
pubmed: 12240924
Hailat N, Lafi S, Al-Darraji A, El-Maghraby H, Al-Ani F, Fathalla M. Foetal anasarca in Awassi sheep. Australian Vet J. 1997;75(4):257–9.
doi: 10.1111/j.1751-0813.1997.tb10092.x
Kumar G, Verma A, Singh R, Pratap Singh B. Dystocia due to foetal anasarca in goat: a case report. J Entomol Zool Stud. 2020;8(4):241–2.
Brough A, Llewellyn R, Nakahara N, Aveston F. Fetal anasarca in an Abyssinian. Kitten Clin Theriogenology. 2016;8(4):425–9.
Hopper BJ, Richardson JL, Lester NV. Spontaneous antenatal resolution of canine hydrops fetalis diagnosed by ultrasound. J Small Anim Pract. 2004;45(1):2–8.
doi: 10.1111/j.1748-5827.2004.tb00187.x
pubmed: 14756202
Heng HG, Randall E, Williams K, Johnson C. What is your diagnosis? Hydrops fetalisJ. Am Vet Med Assoc. 2011;239(1):51–2.
doi: 10.2460/javma.239.1.51
Siena G, Corrò M, Zanardello C, Foiani G, Romagnoli S, Ferré-Dolcet L, et al. A case report of a rapid development of fetal anasarca in a canine pregnancy at term. Vet Res Commun. 2022;46(2):597–602.
doi: 10.1007/s11259-021-09860-w
pubmed: 34855120
Bukowski R, Saade GR. HYDROPS FETALIS. Clin Perinatol. 2000;27(4):1007–31.
doi: 10.1016/S0095-5108(05)70061-0
pubmed: 11816486
Tolia VN, Hunter Clark R, Perelmuter B, Frankfurt JA, Ahmad KA, Abrams ME, et al. Hydrops fetalis—trends in associated diagnoses and mortality from 1997–2018. J Perinatol. 2021;41(10):2537–43.
doi: 10.1038/s41372-021-01179-3
pubmed: 34385586
Yuan SM. Cardiac etiologies of Hydrops Fetalis. Z Geburtshilfe Neonatol. 2017;221(02):67–72.
doi: 10.1055/s-0042-123825
pubmed: 28561210
Pruksanusak N, Suntharasaj T, Suwanrath C, Phukaoloun M, Kanjanapradit K. Fetal Cardiac Rhabdomyoma with Hydrops Fetalis: report of 2 cases and literature review. J Ultrasound Med. 2012;31(11):1821–4.
doi: 10.7863/jum.2012.31.11.1821
pubmed: 23091254
Lefizelier E, Benbrik N, Bénéteau C, Le Vaillant C. Cardiac rhabdomyoma with hydrops fetalis: prenatal management by abdominal drainage. Taiwan J Obstet Gynecol. 2021;60(3):551–3.
doi: 10.1016/j.tjog.2021.03.030
pubmed: 33966747
Fleischer AC, Killam AP, Boehm FH, Hutchison AA, Jones TB, Shaff MI, et al. Hydrops fetalis: sonographic evaluation and clinical implications. Radiology. 1981;141(1):163–8.
doi: 10.1148/radiology.141.1.7291521
pubmed: 7291521
Fabián O, Gebauer R. A practical approach to the examination of the congenitally malformed heart at autopsy. Cesk Patol. 2019;55(4):202–8.
pubmed: 31842550
Shanmugasundaram S, Venkataswamy C, Gurusamy U. Pathologist’s role in identifying cardiac defects—a fetal autopsy series. Cardiovasc Pathol. 2021;51:107312.
doi: 10.1016/j.carpath.2020.107312
pubmed: 33212288
Chetboul V, Damoiseaux C, Poissonnier C, Layennes M, Betrand S, Borenstein N, Behr L, Pouchelon J, Gouni V, Desquilbet L. LSpecific features and survival of French bulldogs with congenital pulmonic stenosis: a prospective cohort study of 66 cases. J Vet Cardiol 201820(6):405–14.
Ontiveros E, Fousse S, Crofton A, Hodge T, Gunther-Harrington C, Visser L, Stern J. Congenital Cardiac Outflow Tract abnormalities in Dogs: prevalence and pattern of inheritance from 2008 to 2017 front vet sci. Feb. 2019;27:652.
Stern J, White S, Lehmkuhl L, Reina-Doreste Y, Ferguson Y, Nascone-Yoder N, Meurs K. A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs. Hum Genet. 2014;133(9):1139–48.
doi: 10.1007/s00439-014-1454-0
pubmed: 24898977
pmcid: 4148152
Lee KJ, Sasaki M, Miyauchi A, Kishimoto M, Shimizu J, Iwasaki T, et al. Virtopsy in a red kangaroo with oral osteomyelitis. J Zoo Wildl Med. 2011;42(1):128–30.
doi: 10.1638/2010-0015.1
pubmed: 22946383
Han HJ, Kim JH. Concurrent pulmonary hypoplasia and congenital lobar emphysema in a young dog with tension pneumothorax: a rare congenital pulmonary anomaly. Acta Vet Scand. 2019;61(1):37.
doi: 10.1186/s13028-019-0472-2
pubmed: 31349870
pmcid: 6659239
Ruchonnet-Metrailler I, Bessieres B, Bonnet D, Vibhushan S, Delacourt C. Pulmonary Hypoplasia Associated with Congenital Heart Diseases: A Fetal Study. Warburton D, editor. PLoS ONE. 2014 3;9(4):e93557.
Santo S, Mansour S, Thilaganathan B, Homfray T, Papageorghiou A, Calvert S, et al. Prenatal diagnosis of non-immune hydrops fetalis: what do we tell the parents? Perinatal outcome of non-immune hydrops. Prenat Diagn. 2011;31(2):186–95.
doi: 10.1002/pd.2677
pubmed: 21268039
Poncelet AJ, Henkens A, Sluysmans T, Moniotte S, de Beco G, Momeni M, et al. Distal aortic Arch Hypoplasia and Coarctation Repair: a tailored enlargement technique. World J Pediatr Congenit Heart Surg. 2018;9(5):496–503.
doi: 10.1177/2150135118780611
pubmed: 30157733
Couperus LE, Vliegen HW, Zandstra TE, Kiès P, Jongbloed MRM, Holman ER, et al. Long-term outcome after atrial correction for transposition of the great arteries. Heart. 2019;105(10):790–6.
doi: 10.1136/heartjnl-2018-313647
pubmed: 30415204