Cerebellar Mutism Syndrome and Dentato-Thalamo-Cortical Tract Disruption in Diffusion Tractography Following Surgery for Medulloblastoma.

Humans Medulloblastoma / surgery Male Female Mutism / etiology Diffusion Tensor Imaging / methods Retrospective Studies Child Case-Control Studies Adolescent Cerebellar Neoplasms / diagnostic imaging Postoperative Complications / diagnostic imaging Neural Pathways / diagnostic imaging Thalamus / diagnostic imaging

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
May 2024
Historique:
medline: 15 5 2024
pubmed: 15 5 2024
entrez: 14 5 2024
Statut: ppublish

Résumé

Background Cerebellar mutism syndrome (CMS), a complication following medulloblastoma surgery, has been linked to dentato-thalamo-cortical tract (DTCT) injury; the association of the degree of DTCT injury with severity of CMS-related symptoms has not been investigated. Purpose To investigate the association between severity of CMS-related symptoms and degree and patterns of DTCT injury with use of diffusion tensor imaging (DTI), and if laterality of injury influences neurologic symptoms. Materials and Methods This retrospective case-control study used prospectively collected clinical and DTI data on patients with medulloblastoma enrolled in a clinical trial (between July 2016 and February 2020) and healthy controls (between April and November 2017), matched with the age range of the participants with medulloblastoma. CMS was divided into types 1 (CMS1) and 2 (CMS2). Multivariable logistic regression was used to investigate the relationship between CMS likelihood and DTCT injury. Results Overall, 82 participants with medulloblastoma (mean age, 11.0 years ± 5.2 [SD]; 53 male) and 35 healthy controls (mean age, 18.0 years ± 3.06; 18 female) were included. In participants with medulloblastoma, DTCT was absent bilaterally (AB), absent on the right side (AR), absent on the left side (AL), or present bilaterally (PB), while it was PB in all healthy controls. Odds of having CMS were associated with higher degree of DTCT damage (AB, odds ratio = 272.7 [95% CI: 269.68, 275.75;

Identifiants

DOI: 10.1148/radiol.232521 PMID: 38742969
pubmed: 38742969
doi: 10.1148/radiol.232521
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e232521

Auteurs

Qing Ji (Q)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Samuel S McAfee (SS)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Matthew Scoggins (M)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
ORCID: 0000-0003-1783-4274

Joseph Holtrop (J)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

John O Glass (JO)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Xiaomeng Yuan (X)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Jia Liang (J)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Yimei Li (Y)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Jason Chiang (J)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Brent A Orr (BA)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Angela Edwards (A)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Diana Storment (D)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Tara Brinkman (T)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Giles W Robinson (GW)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Amar Gajjar (A)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Wilburn E Reddick (WE)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
ORCID: 0000-0002-1054-1201

Zoltán Patay (Z)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Raja B Khan (RB)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.

Asim K Bag (AK)

From the Departments of Diagnostic Imaging (Q.J., S.S.M., M.S., J.H., J.O.G., A.E., D.S., W.E.R., Z.P., A.K.B.), Biostatistics (X.Y., J.L., Y.L.), Pathology (J.C., B.A.O.), Epidemiology and Cancer Control (T.B.), Oncology (G.W.R., A.G.), Neurology (R.B.K.), and Pediatric Medicine (R.B.K.), St. Jude Children's Research Hospital, 262 Danny Thomas Pl, MS 220, Memphis, TN 38105.
ORCID: 0000-0001-6164-5863

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Médulloblastome › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Mutisme › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Tumeurs sous-tentorielles › Tumeurs du cervelet › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Cerebellar Mutism Syndrome and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Thalamus › Cerebellar Mutism Syndrome and...