CD5L as a promising biological therapeutic for treating sepsis.
Animals
Sepsis
/ immunology
Mice, Inbred C57BL
Mice
Neutrophils
/ immunology
Mice, Knockout
Phagocytosis
Chemokine CXCL1
/ metabolism
Disease Models, Animal
Male
Neutrophil Infiltration
/ drug effects
Cecum
/ surgery
Recombinant Proteins
/ therapeutic use
Humans
Pore Forming Cytotoxic Proteins
/ metabolism
Ligation
Lipopolysaccharides
Shock, Septic
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 May 2024
15 May 2024
Historique:
received:
17
02
2023
accepted:
29
04
2024
medline:
16
5
2024
pubmed:
16
5
2024
entrez:
15
5
2024
Statut:
epublish
Résumé
Sepsis results from systemic, dysregulated inflammatory responses to infection, culminating in multiple organ failure. Here, we demonstrate the utility of CD5L for treating experimental sepsis caused by cecal ligation and puncture (CLP). We show that CD5L's important features include its ability to enhance neutrophil recruitment and activation by increasing circulating levels of CXCL1, and to promote neutrophil phagocytosis. CD5L-deficient mice exhibit impaired neutrophil recruitment and compromised bacterial control, rendering them susceptible to attenuated CLP. CD5L
Identifiants
pubmed: 38750020
doi: 10.1038/s41467-024-48360-8
pii: 10.1038/s41467-024-48360-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4119Informations de copyright
© 2024. The Author(s).
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