Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 05 2024
15 05 2024
Historique:
received:
12
02
2024
accepted:
12
05
2024
medline:
16
5
2024
pubmed:
16
5
2024
entrez:
15
5
2024
Statut:
epublish
Résumé
Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality, but the underlying cause(s) are unclear. A subset of SIDS infants has abnormalities in the neurotransmitter, serotonin (5-hydroxytryptamine [5-HT]) and the adaptor molecule, 14-3-3 pathways in regions of the brain involved in gasping, response to hypoxia, and arousal. To evaluate our hypothesis that SIDS is, at least in part, a multi-organ dysregulation of 5-HT, we examined whether blood platelets, which have 5-HT and 14-3-3 signaling pathways similar to brain neurons, are abnormal in SIDS. We also studied platelet surface glycoprotein IX (GPIX), a cell adhesion receptor which is physically linked to 14-3-3. In infants dying of SIDS compared to infants dying of known causes, we found significantly higher intra-platelet 5-HT and 14-3-3 and lower platelet surface GPIX. Serum and plasma 5-HT were also elevated in SIDS compared to controls. The presence in SIDS of both platelet and brainstem 5-HT and 14-3-3 abnormalities suggests a global dysregulation of these pathways and the potential for platelets to be used as a model system to study 5-HT and 14-3-3 interactions in SIDS. Platelet and serum biomarkers may aid in the forensic determination of SIDS and have the potential to be predictive of SIDS risk in living infants.
Identifiants
pubmed: 38750089
doi: 10.1038/s41598-024-61949-9
pii: 10.1038/s41598-024-61949-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11092Subventions
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Development Grants
ID : P01-HD036379
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Development Grants
ID : R01-HD020991
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Development Grants
ID : R21-HD096355
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Development Grants
ID : P30-HD18655
Informations de copyright
© 2024. The Author(s).
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