Corpus callosum morphology and relationships to illness phenotypes in individuals with anorexia nervosa.

Humans Anorexia Nervosa / pathology Corpus Callosum / diagnostic imaging Female Magnetic Resonance Imaging Adolescent Adult Young Adult Phenotype Body Mass Index Case-Control Studies White Matter / diagnostic imaging
Eating disorders MRI Morphometry Obsessive–compulsive symptoms Shape concerns

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
15 05 2024
Historique:
received: 10 11 2023
accepted: 10 05 2024
medline: 16 5 2024
pubmed: 16 5 2024
entrez: 15 5 2024
Statut: epublish

Résumé

Anorexia nervosa is an often-severe psychiatric illness characterized by significantly low body weight, fear of gaining weight, and distorted body image. Multiple neuroimaging studies have shown abnormalities in cortical morphology, mostly associated with the starvation state. Investigations of white matter, while more limited in number, have suggested global and regional volume reductions, as well as abnormal diffusivity in multiple regions including the corpus callosum. Yet, no study has specifically examined thickness of the corpus callosum, a large white matter tract instrumental in the inter-hemispheric integration of sensory, motor, and cognitive information. We analyzed MRI data from 48 adolescents and adults with anorexia nervosa and 50 healthy controls, all girls/women, to compare corpus callosum thickness and examined relationships with body mass index (BMI), illness duration, and eating disorder symptoms (controlling for BMI). There were no significant group differences in corpus callosum thickness. In the anorexia nervosa group, severity of body shape concerns was significantly, positively correlated with callosal thickness in the rostrum, genu, rostral body, isthmus, and splenium. In addition, there were significant positive correlations between eating disorder-related obsessions and compulsions and thickness of the anterior midbody, rostral body, and splenium. There were no significant associations between callosal thickness and BMI or illness duration. In sum, those with AN with worse concerns about bodily appearance and worse eating disorder-related obsessive thought patterns and compulsive behaviours have regionally thicker corpus callosum, independent of current weight status. These findings provide important neurobiological links to key, specific eating disorder behavioural phenotypes.

Identifiants

DOI: 10.1038/s41598-024-61841-6 PMID: 38750237
pubmed: 38750237
doi: 10.1038/s41598-024-61841-6
pii: 10.1038/s41598-024-61841-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11112

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jamie D Feusner (JD)

Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada. jamie.feusner@utoronto.ca.
Department of Psychiatry, University of Toronto, Toronto, Canada. jamie.feusner@utoronto.ca.
Department of Women's and Children's Health, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden. jamie.feusner@utoronto.ca.
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA. jamie.feusner@utoronto.ca.

Alicja Nowacka (A)

School of Psychology, University of Auckland, Auckland, New Zealand.

Ronald Ly (R)

Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.

Eileen Luders (E)

School of Psychology, University of Auckland, Auckland, New Zealand.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Laboratory of Neuro Imaging, School of Medicine, University of Southern California, Los Angeles, CA, USA.

Florian Kurth (F)

School of Psychology, University of Auckland, Auckland, New Zealand.
Departments of Neuroradiology and Radiology, Jena University Hospital, Jena, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Corpus callosum morphology and relationships...
questionsmedicales.fr › Troubles mentaux › Troubles de l'alimentation › Anorexie mentale › Corpus callosum morphology and relationships...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Commissures du télencéphale › Corps calleux › Corpus callosum morphology and relationships...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Corpus callosum morphology and relationships...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Corpus callosum morphology and relationships...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Corpus callosum morphology and relationships...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Corpus callosum morphology and relationships...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Corpus callosum morphology and relationships...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Corpus callosum morphology and relationships...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Corpus callosum morphology and relationships...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Corpus callosum morphology and relationships...