Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.

Humans Amyotrophic Lateral Sclerosis / metabolism RNA-Binding Protein FUS / metabolism Glycolates / metabolism Mitochondria / metabolism Protein Deglycase DJ-1 / metabolism Lactic Acid / metabolism Superoxide Dismutase-1 / metabolism Membrane Potential, Mitochondrial Motor Neurons / metabolism Lysosomes / metabolism

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Aug 2024
Historique:
received: 15 12 2023
revised: 05 05 2024
accepted: 07 05 2024
medline: 18 5 2024
pubmed: 18 5 2024
entrez: 17 5 2024
Statut: epublish

Résumé

Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the pathophysiology of

Identifiants

DOI: 10.26508/lsa.202302535 PMID: 38760174
pubmed: 38760174
pii: 7/8/e202302535
doi: 10.26508/lsa.202302535
pii:
doi:

Substances chimiques

glycolic acid 0
FUS protein, human 0
SOD1 protein, human 0
PARK7 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Pal et al.

Auteurs

Arun Pal (A)

Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Dresden High Magnetic Field Laboratory (HLD-EMFL), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.

Dajana Grossmann (D)

Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.

Hannes Glaß (H)

Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.

Vitaly Zimyanin (V)

Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
https://ror.org/0153tk833 Department of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, USA.
https://ror.org/0153tk833 Center for Membrane and Cell Physiology, University of Virginia, School of Medicine, Charlottesville, VA, USA.

René Günther (R)

Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany.
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Dresden, Germany.

Marica Catinozzi (M)

Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands.

Tobias M Boeckers (TM)

Institute for Anatomy and Cell Biology, Ulm University, as well as Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm, Germany.

Jared Sterneckert (J)

Center for Regenerative Therapies Dresden, Technische Universität Dresden as well as Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany.
ORCID: 0000-0002-7688-3124

Erik Storkebaum (E)

Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands.
ORCID: 0000-0002-9519-5642

Susanne Petri (S)

Department of Neurology, Hannover Medical School, Hannover, Germany.

Florian Wegner (F)

Department of Neurology, Hannover Medical School, Hannover, Germany.

Stephan W Grill (SW)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany.

Francisco Pan-Montojo (F)

Department of Psychiatrie and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.

Andreas Hermann (A)

Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany Andreas.Hermann@med.uni-rostock.de.
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock/Greifswald, Rostock, Germany.
Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany.
ORCID: 0000-0002-7364-7791

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › Protéine FUS de liaison à l'ARN › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Glycolates › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › Protein deglycase DJ-1 › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Potentiel de membrane mitochondriale › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Glycolic acid and D-lactate-putative products...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Glycolic acid and D-lactate-putative products...