PARP1-DNA co-condensation: the driver of broken DNA repair.
Journal
Signal transduction and targeted therapy
ISSN: 2059-3635
Titre abrégé: Signal Transduct Target Ther
Pays: England
ID NLM: 101676423
Informations de publication
Date de publication:
17 May 2024
17 May 2024
Historique:
received:
27
02
2024
accepted:
17
04
2024
revised:
14
04
2024
medline:
18
5
2024
pubmed:
18
5
2024
entrez:
17
5
2024
Statut:
epublish
Résumé
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends together and generate enzymatic activity for the synthesis of PAR. PARylation can promote the release of PARP1 from DNA ends and recruit various proteins, such as Fused in sarcoma (FUS) proteins, thereby stabilizing broken DNA ends and preventing their separation.
Identifiants
pubmed: 38760366
doi: 10.1038/s41392-024-01832-1
pii: 10.1038/s41392-024-01832-1
doi:
Substances chimiques
PARP1 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135Subventions
Organisme : Chinese Ministry of Science and Technology | Department of S and T for Social Development (Department of S&T for Social Development)
ID : 2021YFA1101000
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : U20A20393,31925013
Informations de copyright
© 2024. The Author(s).
Références
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