Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 May 2024
20 May 2024
Historique:
received:
07
08
2022
accepted:
19
04
2024
medline:
21
5
2024
pubmed:
21
5
2024
entrez:
20
5
2024
Statut:
epublish
Résumé
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifications, including aminoacylated CP-tRNA
Identifiants
pubmed: 38769321
doi: 10.1038/s41467-024-48163-x
pii: 10.1038/s41467-024-48163-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4272Subventions
Organisme : Stiftelsen för Strategisk Forskning (Swedish Foundation for Strategic Research)
ID : FFL15:0325
Organisme : Ragnar Söderbergs stiftelse (Ragnar Söderberg Foundation)
ID : M44/16
Organisme : Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)
ID : 2018.0080
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : ERC-2018-StG-805230
Organisme : MEXT | Japan Science and Technology Agency (JST)
ID : 19198049
Organisme : DH | NIHR | Health Services Research Programme (NIHR Health Services Research Programme)
ID : GM118141
Organisme : United States Department of Defense | Missile Defense Agency (MDA)
ID : MDA-381828
Informations de copyright
© 2024. The Author(s).
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