Screening Antibacterial Photodynamic Effect of Monascus Red Yeast Rice (Hong-Qu) and Mycelium Extracts.
Monascus
/ chemistry
Anti-Bacterial Agents
/ pharmacology
Mycelium
/ chemistry
Microbial Sensitivity Tests
Photosensitizing Agents
/ pharmacology
Biological Products
/ pharmacology
Gram-Positive Bacteria
/ drug effects
Complex Mixtures
/ pharmacology
Pigments, Biological
/ pharmacology
Photochemotherapy
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
21 May 2024
21 May 2024
Historique:
received:
12
02
2024
accepted:
29
04
2024
medline:
21
5
2024
pubmed:
21
5
2024
entrez:
21
5
2024
Statut:
epublish
Résumé
The fungus Monascus is a well-known source of secondary metabolites with interesting pharmaceutical and nutraceutical applications. In particular, Monascus pigments possess a wide range of biological activities (e.g. antimicrobial, antioxidant, anti-inflammatory or antitumoral). To broaden the scope of their possible application, this study focused on testing Monascus pigment extracts as potential photosensitizing agents efficient in antimicrobial photodynamic therapy (aPDT) against bacteria. For this purpose, eight different extracts of secondary metabolites from the liquid- and solid-state fermentation of Monascus purpureus DBM 4360 and Monascus sp. DBM 4361 were tested against Gram-positive and Gram-negative model bacteria, Bacillus subtilis and Escherichia coli and further screened for ESKAPE pathogens, Staphylococcus aureus and Pseudomonas aeruginosa. To the bacterial culture, increasing concentration of extracts was added and it was found that all extracts showed varying antimicrobial activity against Gram-positive bacteria in dark, which was further increased after irradiation. Gram-negative bacteria were tolerant to the extracts' exposure in the dark but sensitivity to almost all extracts that occurred after irradiation. The Monascus sp. DBM 4361 extracts seemed to be the best potential candidate for aPDT against Gram-positive bacteria, being efficient at low doses, i.e. the lowest total concentration of Monascus pigments exhibiting aPDT effect was 3.92 ± 1.36 mg/L for E. coli. Our results indicate that Monascus spp., forming monascuspiloin as the major yellow pigment and not-forming mycotoxin citrinin, is a promising source of antimicrobials and photoantimicrobials.
Identifiants
pubmed: 38771359
doi: 10.1007/s00284-024-03725-6
pii: 10.1007/s00284-024-03725-6
doi:
Substances chimiques
red yeast rice
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
183Subventions
Organisme : Vysoká Škola Chemicko-technologická v Praze
ID : A2_FPBT_2022_016
Informations de copyright
© 2024. The Author(s).
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