Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia.

Animals Macrophages / immunology Mice Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / metabolism Myocardial Ischemia / immunology Myocardial Infarction / pathology Male Myocardial Reperfusion Injury / immunology Mice, Inbred C57BL Myocardium / pathology Disease Models, Animal
developmental biology immunology inflammation macrophage mouse myocardial infarction

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
22 May 2024
Historique:
medline: 22 5 2024
pubmed: 22 5 2024
entrez: 22 5 2024
Statut: epublish

Résumé

Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion (I/R) injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. Genomic deletion of a fms-intronic regulatory element (FIRE) in the

Identifiants

DOI: 10.7554/eLife.89377 PMID: 38775664
pubmed: 38775664
doi: 10.7554/eLife.89377
pii: 89377
doi:
pii:

Substances chimiques

Csf1r protein, mouse 0

Banques de données

GEO
['GSE263544', 'GSE263545']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsches Zentrum für Herz-Kreislaufforschung
ID : 81Z0600204
Organisme : Deutsches Zentrum für Herz-Kreislaufforschung
ID : 81X2600252
Organisme : Deutsches Zentrum für Herz-Kreislaufforschung
ID : 81X2600256
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHU 2297/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 1123 project Z02
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 1123 project A07
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB TRR332, project A06
Organisme : European Society of Cardiology
ID : Research Grant 2021

Informations de copyright

© 2023, Weinberger et al.

Déclaration de conflit d'intérêts

TW, MD, MJ, MF, CG, KK, VW, SA, SR, JF, LL, WL, JW, JL, LT, DE, GP, SM, AH, CW, SE, AT, RZ, CP, EG, CS No competing interests declared

Auteurs

Tobias Weinberger (T)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.
DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.
Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France.
ORCID: 0000-0003-0024-020X

Messerer Denise (M)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Markus Joppich (M)

LFE Bioinformatik, Department of Informatics, Ludwig Maximilian University, Munich, Germany.
ORCID: 0000-0002-6665-8951

Maximilian Fischer (M)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.
DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.
ORCID: 0000-0001-9172-3316

Clarisabel Garcia Rodriguez (C)

Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France.

Konda Kumaraswami (K)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Vanessa Wimmler (V)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Sonja Ablinger (S)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Saskia Räuber (S)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.
Department of Neurology, Medical Faculty, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0001-8901-5572

Jiahui Fang (J)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Lulu Liu (L)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Wing Han Liu (WH)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.

Julia Winterhalter (J)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.

Johannes Lichti (J)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.

Lukas Thomas (L)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.
DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.

Dena Esfandyari (D)

DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.
Institute of Pharmacology and Toxicology, Technical University Munich, Munich, Germany.
ORCID: 0000-0001-8732-1461

Guelce Percin (G)

Immunology of Aging, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), Jena, Germany.

Sandra Matin (S)

Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

Andrés Hidalgo (A)

Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, United States.

Claudia Waskow (C)

Immunology of Aging, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), Jena, Germany.
Faculty of Biological Sciences, Friedrich-Schiller-University, Jena, Germany.

Stefan Engelhardt (S)

DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.
Institute of Pharmacology and Toxicology, Technical University Munich, Munich, Germany.
ORCID: 0000-0001-5378-8661

Andrei Todica (A)

Department of Nuclear Medicine, Ludwig Maximilian University, Munich, Germany.

Ralf Zimmer (R)

LFE Bioinformatik, Department of Informatics, Ludwig Maximilian University, Munich, Germany.

Clare Pridans (C)

Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
ORCID: 0000-0001-9423-557X

Elisa Gomez Perdiguero (E)

Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France.

Christian Schulz (C)

Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University, Munich, Germany.
DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.
Department of Immunopharmacology, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
ORCID: 0000-0002-8149-0747

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Resident and recruited macrophages...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Resident and recruited macrophages...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Resident and recruited macrophages...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance hématopoïétique › Récepteur de facteur de croissance granulocyte-macrophage › Resident and recruited macrophages...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Resident and recruited macrophages...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Resident and recruited macrophages...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Lésion de reperfusion myocardique › Resident and recruited macrophages...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Resident and recruited macrophages...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Resident and recruited macrophages...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Resident and recruited macrophages...