Untangling the Evolution of the Receptor-Binding Motif of SARS-CoV-2.

Bayes factors Dissonance Information content Recombination Viral evolution

Journal

Journal of molecular evolution

ISSN: 1432-1432

Titre abrégé: J Mol Evol

Pays: Germany

ID NLM: 0360051

Informations de publication

Date de publication:
22 May 2024

Historique:

received: 17 07 2023

accepted: 04 05 2024

medline: 23 5 2024

pubmed: 23 5 2024

entrez: 22 5 2024

Statut: aheadofprint

Résumé

The spike protein determines the host-range specificity of coronaviruses. In particular, the Receptor-Binding Motif in the spike protein from SARS-CoV-2 contains the amino acids involved in molecular recognition of the host Angiotensin Converting Enzyme 2. Therefore, to understand how SARS-CoV-2 acquired its capacity to infect humans it is necessary to reconstruct the evolution of this important motif. Early during the pandemic, it was proposed that the SARS-CoV-2 Receptor-Binding Domain was acquired via recombination with a pangolin infecting coronavirus. This proposal was challenged by an alternative explanation that suggested that the Receptor-Binding Domain from SARS-CoV-2 did not originated via recombination with a coronavirus from a pangolin. Instead, this alternative hypothesis proposed that the Receptor-Binding Motif from the bat coronavirus RaTG13, was acquired via recombination with an unidentified coronavirus. And as a consequence of this event, the Receptor-Binding Domain from the pangolin coronavirus appeared as phylogenetically closer to SARS-CoV-2. Recently, the genomes from coronaviruses from Cambodia (bat_RShST182/200) and Laos (BANAL-20-52/103/247) which are closely related to SARS-CoV-2 were reported. However, no detailed analysis of the evolution of the Receptor-Binding Motif from these coronaviruses was reported. Here we revisit the evolution of the Receptor-Binding Domain and Motif in the light of the novel coronavirus genome sequences. Specifically, we wanted to test whether the above coronaviruses from Cambodia and Laos were the source of the Receptor-Binding Domain from RaTG13. We found that the Receptor-Binding Motif from these coronaviruses is phylogenetically closer to SARS-CoV-2 than to RaTG13. Therefore, the source of the Receptor-Binding Domain from RaTG13 is still unidentified. In accordance with previous studies, our results are consistent with the hypothesis that the Receptor-Binding Motif from SARS-CoV-2 evolved by vertical inheritance from a bat-infecting population of coronaviruses.

Identifiants

DOI: 10.1007/s00239-024-10175-y PMID: 38777906

pubmed: 38777906

doi: 10.1007/s00239-024-10175-y

pii: 10.1007/s00239-024-10175-y

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : CONAHCYT

ID : l1200/320/2022

Organisme : CONAHCYT

ID : l1200/224/2021

Informations de copyright

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