Structural insights into the cross-exon to cross-intron spliceosome switch.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
22 May 2024
Historique:
received: 17 11 2023
accepted: 23 04 2024
medline: 23 5 2024
pubmed: 23 5 2024
entrez: 22 5 2024
Statut: aheadofprint

Résumé

Early spliceosome assembly can occur through an intron-defined pathway, whereby U1 and U2 small nuclear ribonucleoprotein particles (snRNPs) assemble across the intron

Identifiants

pubmed: 38778104
doi: 10.1038/s41586-024-07458-1
pii: 10.1038/s41586-024-07458-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Zhenwei Zhang (Z)

Department of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.
State Key Laboratory of Biotherapy and Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.

Vinay Kumar (V)

Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.

Olexandr Dybkov (O)

Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Bioanalytical Mass Spectrometry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.

Cindy L Will (CL)

Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.

Jiayun Zhong (J)

State Key Laboratory of Biotherapy and Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.

Sebastian E J Ludwig (SEJ)

Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Vincerx Pharma, Monheim am Rhein, Germany.

Henning Urlaub (H)

Bioanalytical Mass Spectrometry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Bioanalytics Group, Institute for Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany.

Berthold Kastner (B)

Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany.

Holger Stark (H)

Department of Structural Dynamics, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. hstark1@gwdg.de.

Reinhard Lührmann (R)

Cellular Biochemistry, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. reinhard.luehrmann@mpinat.mpg.de.

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