Investigations of Antioxidant and Anti-Cancer Activities of 5-Aminopyrazole Derivatives.

Humans Pyrazoles / chemistry Antineoplastic Agents / pharmacology Antioxidants / pharmacology Structure-Activity Relationship Cell Line, Tumor Cell Proliferation / drug effects Molecular Structure
5-aminopyrazoles DPPH MTT test ROS anti-cancer activity druglike properties

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
14 May 2024
Historique:
received: 04 04 2024
revised: 09 05 2024
accepted: 11 05 2024
medline: 25 5 2024
pubmed: 25 5 2024
entrez: 25 5 2024
Statut: epublish

Résumé

To further extend the structure-activity relationships (SARs) of 5-aminopyrazoles (5APs) and identify novel compounds able to interfere with inflammation, oxidative stress, and tumorigenesis, 5APs

Identifiants

DOI: 10.3390/molecules29102298 PMID: 38792163
pubmed: 38792163
pii: molecules29102298
doi: 10.3390/molecules29102298
pii:
doi:

Substances chimiques

Pyrazoles 0
Antineoplastic Agents 0
Antioxidants 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian Minister of Health
ID : Ricerca Corrente

Auteurs

Federica Rapetti (F)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
ORCID: 0000-0002-4032-323X

Andrea Spallarossa (A)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
ORCID: 0000-0002-3360-7146

Eleonora Russo (E)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
ORCID: 0000-0002-5856-7929

Debora Caviglia (D)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.

Carla Villa (C)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
ORCID: 0000-0002-4951-3515

Bruno Tasso (B)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
ORCID: 0000-0002-5636-5645

Maria Grazia Signorello (MG)

Department of Pharmacy (DIFAR), Biochemistry Lab., University of Genoa, Viale Benedetto XV, 3, 16132 Genova, Italy.

Camillo Rosano (C)

IRCCS Ospedale Policlinico San Martino, Proteomics and Mass Spectrometry Unit, L.go. R. Benzi, 10, 16132 Genova, Italy.
ORCID: 0000-0003-2949-9215

Erika Iervasi (E)

IRCCS Ospedale Policlinico San Martino, Proteomics and Mass Spectrometry Unit, L.go. R. Benzi, 10, 16132 Genova, Italy.

Marco Ponassi (M)

IRCCS Ospedale Policlinico San Martino, Proteomics and Mass Spectrometry Unit, L.go. R. Benzi, 10, 16132 Genova, Italy.

Chiara Brullo (C)

Department of Pharmacy (DIFAR), University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
ORCID: 0000-0002-2575-7726

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Investigations of Antioxidant and Anti-Cancer...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Investigations of Antioxidant and Anti-Cancer...