Pharmacodynamic monitoring by residual gene expression of the nuclear factor of activated T cell-regulated genes in lung transplant recipients and its correlation with tacrolimus blood levels.
Humans
Tacrolimus
/ therapeutic use
Lung Transplantation
/ adverse effects
Male
NFATC Transcription Factors
/ genetics
Middle Aged
Female
Immunosuppressive Agents
/ therapeutic use
Adult
Aged
Transplant Recipients
Drug Monitoring
/ methods
Graft Rejection
/ immunology
Gene Expression Regulation
/ drug effects
T-Lymphocytes
/ immunology
biomarker
infection
pharmacodynamics
pharmacokinetics
rejection
tacrolimus
therapeutic drug monitoring
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
05
02
2024
accepted:
22
04
2024
medline:
27
5
2024
pubmed:
27
5
2024
entrez:
27
5
2024
Statut:
epublish
Résumé
Trough blood levels (C NFAT-RGE and tacrolimus C Tacrolimus C Consequently, a subset of patients within the tacrolimus therapeutic range may be more susceptible to infection or cancer, potentially benefiting from NFAT-RGE and tacrolimus peak level monitoring to tailor their dosage. Further quantitative risk assessment studies are needed to elucidate the relationship between NFAT-RGE and the risk of infection, cancer, or rejection.
Identifiants
pubmed: 38799459
doi: 10.3389/fimmu.2024.1382459
pmc: PMC11116644
doi:
Substances chimiques
Tacrolimus
WM0HAQ4WNM
NFATC Transcription Factors
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1382459Informations de copyright
Copyright © 2024 Boada-Pérez, Ruiz de Miguel, Erro, Ussetti, Aguilar, Castejón, Rosado, Escobar-Fornieles, Revilla-López, Bravo, Sáez-Giménez, Zapata-Ortega, Villena-Ortiz, Vima-Bofarull, Monforte and Gómez-Ollés.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer OM declared a shared affiliation, with no collaboration, with some of the authors CB, VM, SG-O to the handling editor at the time of the review.