Risk Factors, Incidence, and Outcomes Associated With Clinically Significant Airway Ischemia.

Airway complications following lung transplantation remain an important cause of morbidity and mortality. We aimed to identify the incidence, risk factors and outcomes associated with clinically significant airway ischemia (CSAI) in our center. We reviewed 217 lung transplants (386 airway anastomoses) performed at our institution between February 2016 and December 2020. Airway images were graded using the 2018 ISHLT grading guidelines modified slightly for retrospective analysis. Airways were considered to have CSAI if they developed ischemia severity >B2, stenosis >50%, and/or any degree of dehiscence within 6-months of transplant. Regression analyses were used to evaluate outcomes and risk factors for CSAI. Eighty-two patients (37.8%) met criteria for CSAI. Of these, twenty-six (32%) developed stenosis and/or dehiscence, and 17 (21%) required interventions. Patients with CSAI had lower one-year (80.5% vs. 91.9%,

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Copyright © 2024 Li, Liu, Salan-Gomez, Keeney, D’Silva, Mankidy, Leon, Mattar, Elsennousi, Coster, Kumar, Rodrigues, Li, Shafii, Garcha and Loor.

Déclaration de conflit d'intérêts

GaL, MD is a consultant for Transmedics, Inc. and Abiomed Breathe. GaL receives institutional grant support to Baylor College of Medicine from the American Association of Thoracic Surgeons, the Roderick McDonald Foundation, and Abbot. He is a recipient of the George P. Noon Endowment from Baylor College of Medicine Michael E. DeBakey Foundation. GaL’s institution Baylor College of Medicine receives grant support from the JLH foundation, Transmedics, Abiomed, Atricure, and Getinge. PG is a consultant for United Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.