A pediatric case of two Nicolau syndrome lesions following leuprolide injection in the upper extremity.
Journal
Indian journal of pharmacology
ISSN: 1998-3751
Titre abrégé: Indian J Pharmacol
Pays: India
ID NLM: 7902477
Informations de publication
Date de publication:
01 Mar 2024
01 Mar 2024
Historique:
received:
13
11
2023
accepted:
18
03
2024
medline:
29
5
2024
pubmed:
29
5
2024
entrez:
29
5
2024
Statut:
ppublish
Résumé
Nicolau syndrome (NS) is a rare and unpredictable adverse reaction that can occur after the administration of certain medications. A 9-year-old girl, accompanied by her father, visited the outpatient dermatology clinic with complaints of wounds on both upper arms. Upon reviewing her medical history, it was discovered that she had been receiving leuprolide for precocious puberty, and the symptoms began after the last two injections. The patient experienced pain during the leuprolide injection, and redness and swelling were noticed in the injection area on the same day. A few days later, the redness turned into ulcers. The fact that the development of NS cannot be detected in advance and the risk of rapid progression of tissue necrosis make disease management difficult. The prognosis of NS significantly depends on the patient, and when a developing lesion is noticed early, it is crucial to minimize the risk of complications.
Identifiants
pubmed: 38808926
doi: 10.4103/ijp.ijp_743_23
pii: 01363791-202456020-00011
doi:
Substances chimiques
Leuprolide
EFY6W0M8TG
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-143Informations de copyright
Copyright © 2024 Copyright: © 2024 Indian Journal of Pharmacology.
Références
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Hatefi M, Pirabadi NR, Khajavikhan J, Jaafarpour M. Claudication due to sciatic nerve palsy following Nicolau syndrome:A case report. J Clin Diagn Res 2015;9:D01–2.