Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis.


Journal

International journal of colorectal disease
ISSN: 1432-1262
Titre abrégé: Int J Colorectal Dis
Pays: Germany
ID NLM: 8607899

Informations de publication

Date de publication:
29 May 2024
Historique:
accepted: 23 05 2024
medline: 29 5 2024
pubmed: 29 5 2024
entrez: 29 5 2024
Statut: epublish

Résumé

Circulating tumour DNA (ctDNA) has emerged as a promising biomarker in various cancer types, including locally advanced rectal cancer (LARC), offering potential insights into disease progression, treatment response and recurrence. This review aims to comprehensively evaluate the utility of ctDNA as a prognostic biomarker in LARC. PubMed, EMBASE and Web of Science were searched as part of our review. Studies investigating the utility of ctDNA in locally advanced rectal cancer (LARC) were assessed for eligibility. Quality assessment of included studies was performed using the Newcastle Ottawa Scale (NOS) risk of bias tool. Outcomes extracted included basic participant characteristics, ctDNA details and survival data. A meta-analysis was performed on eligible studies to determine pooled recurrence-free survival (RFS). Twenty-two studies involving 1676 participants were included in our analysis. Methodological quality categorised by the Newcastle Ottawa Scale was generally satisfactory across included studies. ctDNA detected at various time intervals was generally associated with poor outcomes across included studies. Meta-analysis demonstrated a pooled hazard ratio of 8.87 (95% CI 4.91-16.03) and 15.15 (95% CI 8.21-27.95), indicating an increased risk of recurrence with ctDNA positivity in the post-neoadjuvant and post-operative periods respectively. Our systematic review provides evidence supporting the prognostic utility of ctDNA in patients with LARC, particularly in identifying patients at higher risk of disease recurrence in the post-neoadjuvant and post-operative periods.

Identifiants

pubmed: 38809315
doi: 10.1007/s00384-024-04656-1
pii: 10.1007/s00384-024-04656-1
doi:

Substances chimiques

Circulating Tumor DNA 0
Biomarkers, Tumor 0

Types de publication

Systematic Review Meta-Analysis Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

82

Informations de copyright

© 2024. The Author(s).

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Auteurs

Niall J O'Sullivan (NJ)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland. nosulli7@tcd.ie.
School of Medicine, Trinity College Dublin, Dublin 2, Ireland. nosulli7@tcd.ie.

Hugo C Temperley (HC)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.
School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

Eimear T Kyle (ET)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

Kevin J Sweeney (KJ)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

Maeve O'Neill (M)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

Charles Gilham (C)

School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Department of Radiation Oncology, St. James's Hospital, Dublin 8, Ireland.

Jacintha O'Sullivan (J)

School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Trinity Translational Medicine Institute, Trinity St. James's Cancer Institute, Trinity College, St. James's Hospital, Dublin, Ireland.

Grainne O'Kane (G)

Department of Medical Oncology, St. James's Hospital, Dublin 8, Ireland.

Brian Mehigan (B)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

Sharon O'Toole (S)

School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Trinity Translational Medicine Institute, Trinity St. James's Cancer Institute, Trinity College, St. James's Hospital, Dublin, Ireland.

John Larkin (J)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

David Gallagher (D)

School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Department of Medical Oncology, St. James's Hospital, Dublin 8, Ireland.
Department of Genetics, St. James's Hospital, Dublin 8, Ireland.

Paul McCormick (P)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.

Michael E Kelly (ME)

Department of Surgery, St. James's Hospital, Dublin 8, Ireland.
School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
Trinity St. James's Cancer Institute, St. James's Hospital, Dublin 8, Ireland.

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