Different roles of endothelial cell-derived fibronectin and plasma fibronectin in endothelial dysfunction.
Endothelial cell activation
atherosclerosis
endothelial dysfunction
fibronectin
inflammation
Journal
Turkish journal of medical sciences
ISSN: 1303-6165
Titre abrégé: Turk J Med Sci
Pays: Turkey
ID NLM: 9441758
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
03
2023
revised:
12
12
2023
accepted:
25
10
2023
medline:
30
5
2024
pubmed:
30
5
2024
entrez:
30
5
2024
Statut:
epublish
Résumé
Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (Fn Initially, endothelial cell injury was induced by exposing the cells to oxidized low-density lipoprotein (ox-LDL) and subsequently we generated a mutant strain of aortic endothelial cells with Fn knockdown (Fn The results showed that the Fn Aortic Fn
Sections du résumé
Background/aim
UNASSIGNED
Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (Fn
Materials and methods
UNASSIGNED
Initially, endothelial cell injury was induced by exposing the cells to oxidized low-density lipoprotein (ox-LDL) and subsequently we generated a mutant strain of aortic endothelial cells with Fn knockdown (Fn
Results
UNASSIGNED
The results showed that the Fn
Conclusion
UNASSIGNED
Aortic Fn
Identifiants
pubmed: 38813506
doi: 10.55730/1300-0144.5735
pii: turkjmedsci-53-6-1667
pmc: PMC10760598
doi:
Substances chimiques
Fibronectins
0
Lipoproteins, LDL
0
oxidized low density lipoprotein
0
Vascular Cell Adhesion Molecule-1
0
Intercellular Adhesion Molecule-1
126547-89-5
NF-kappa B
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1667-1677Informations de copyright
© TÜBİTAK.
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare that there are no conflicts of interest regarding the publication of this paper.