Assembly and catalytic activity of short prion-inspired peptides.

Prions / chemistry Catalysis Peptides / chemistry Amyloid / chemistry Cations, Divalent / chemistry
Amyloid fibrils Biocatalytic nanomaterials Nanoenzymes Peptides Self-assembly

Journal

Methods in enzymology
ISSN: 1557-7988
Titre abrégé: Methods Enzymol
Pays: United States
ID NLM: 0212271

Informations de publication

Date de publication:
2024
Historique:
medline: 31 5 2024
pubmed: 31 5 2024
entrez: 30 5 2024
Statut: ppublish

Résumé

Enzymes play a crucial role in biochemical reactions, but their inherent structural instability limits their performance in industrial processes. In contrast, amyloid structures, known for their exceptional stability, are emerging as promising candidates for synthetic catalysis. This article explores the development of metal-decorated nanozymes formed by short peptides, inspired by prion-like domains. We detail the rational design of synthetic short Tyrosine-rich peptide sequences, focusing on their self-assembly into stable amyloid structures and their metallization with biologically relevant divalent metal cations, such as Cu

Identifiants

DOI: 10.1016/bs.mie.2024.01.015 PMID: 38816134
pubmed: 38816134
pii: S0076-6879(24)00018-1
doi: 10.1016/bs.mie.2024.01.015
pii:
doi:

Substances chimiques

Prions 0
Peptides 0
Amyloid 0
Cations, Divalent 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

499-526

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Javier Garcia-Pardo (J)

Institut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. Electronic address: Javier.Garcia.Pardo@uab.cat.

Marc Fornt-Suñé (M)

Institut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.

Salvador Ventura (S)

Institut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. Electronic address: Salvador.Ventura@uab.cat.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Assembly and catalytic activity of short...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Assembly and catalytic activity of short...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Assembly and catalytic activity of short...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Assembly and catalytic activity of short...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Cations divalents › Assembly and catalytic activity of short...