Retinal blood flow association with age and weight in infants at risk for retinopathy of prematurity.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 06 2024
04 06 2024
Historique:
received:
29
01
2024
accepted:
29
05
2024
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
4
6
2024
Statut:
epublish
Résumé
This prospective study evaluated the relationship between laser speckle contrast imaging (LSCI) ocular blood flow velocity (BFV) and five birth parameters: gestational age (GA), postmenstrual age (PMA) and chronological age (CA) at the time of measurement, birth weight (BW), and current weight (CW) in preterm neonates at risk for retinopathy of prematurity (ROP). 38 Neonates with BW < 2 kg, GA < 32 weeks, and PMA between 27 and 47 weeks underwent 91 LSCI sessions. Correlation tests and regression analysis were performed to quantify relationships between birth parameters and ocular BFV. Mean ocular BFV index in this cohort was 8.8 +/- 4.0 IU. BFV positively correlated with PMA (r = 0.3, p = 0.01), CA (r = 0.3, p = 0.005), and CW (r = 0.3, p = 0.02). BFV did not correlate with GA nor BW (r = - 0.2 and r = - 0.05, p > 0.05). Regression analysis with mixed models demonstrated that BFV increased by 1.2 for every kilogram of CW, by 0.34 for every week of CA, and by 0.36 for every week of PMA (p = 0.03, 0.004, 0.007, respectively). Our findings indicate that increased age and weight are associated with increased ocular BFV measured using LSCI in premature infants. Future studies investigating the associations between ocular BFV and ROP clinical severity must control for age and/or weight of the infant.
Identifiants
pubmed: 38834830
doi: 10.1038/s41598-024-63534-6
pii: 10.1038/s41598-024-63534-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12790Subventions
Organisme : Maryland Industrial Partnerships (MIPS) Program
ID : Grant 7103
Organisme : National Eye Institute (NEI) of the National Institutes of Health
ID : K23EY03252
Organisme : Small Business Innovation Research (SBIR)
ID : R43EY030798
Informations de copyright
© 2024. The Author(s).
Références
Lim, H. W. et al. Causes of childhood blindness in the United States using the IRIS
doi: 10.1016/j.ophtha.2023.04.004
pubmed: 37037315
Solebo, A. L., Teoh, L. & Rahi, J. Epidemiology of blindness in children. Arch. Dis. Child. 102, 853–857 (2017).
doi: 10.1136/archdischild-2016-310532
pubmed: 28465303
Kim, T., Sohn, J., Pi, S. & Yoon, Y. H. Postnatal risk factors of retinopathy of prematurity. Paediatr. Perinat. Epidemiol. 18, 130–134 (2004).
doi: 10.1111/j.1365-3016.2003.00545.x
pubmed: 14996252
Karna, P., Muttineni, J., Angell, L. & Karmaus, W. Retinopathy of prematurity and risk factors: A prospective cohort study. BMC Pediatr. 5, 18 (2005).
doi: 10.1186/1471-2431-5-18
pubmed: 15985170
pmcid: 1175091
Lundgren, P. et al. Low birth weight is a risk factor for severe retinopathy of prematurity depending on gestational age. PLoS One 9, e109460. https://doi.org/10.1371/journal.pone.0109460 (2014).
doi: 10.1371/journal.pone.0109460
pubmed: 25330287
pmcid: 4198133
Good, W. V. et al. The incidence and course of retinopathy of prematurity: Findings from the early treatment for retinopathy of prematurity study. Pediatrics 116, 15–23 (2005).
doi: 10.1542/peds.2004-1413
pubmed: 15995025
Fortes Filho, J. B. et al. Is being small for gestational age a risk factor for retinopathy of prematurity? A study with 345 very low birth weight preterm infants. J. Pediatr. (Rio J.) 85, 48–54 (2009).
doi: 10.2223/JPED.1870
pubmed: 19198736
Hellström, A., Smith, L. E. & Dammann, O. Retinopathy of prematurity. The Lancet 382, 1445–1457 (2013).
doi: 10.1016/S0140-6736(13)60178-6
Chen, J. & Smith, L. E. H. Retinopathy of prematurity. Angiogenesis 10, 133–140 (2007).
doi: 10.1007/s10456-007-9066-0
pubmed: 17332988
Marino, M. J., Gehlbach, P. L., Rege, A. & Jiramongkolchai, K. Current and novel multi-imaging modalities to assess retinal oxygenation and blood flow. Eye 35, 2962–2972 (2021).
doi: 10.1038/s41433-021-01570-6
pubmed: 34117399
pmcid: 8526664
DeBuc, D. C., Rege, A. & Smiddy, W. E. Use of XyCAM RI for noninvasive visualization and analysis of retinal blood flow dynamics during clinical investigations. Expert Rev. Med. Dev. 18, 225–237 (2021).
doi: 10.1080/17434440.2021.1892486
Senarathna, J., Rege, A., Li, N. & Thakor, N. V. Laser speckle contrast imaging: Theory, instrumentation and applications. IEEE Rev. Biomed. Eng. 6, 99–110 (2013).
doi: 10.1109/RBME.2013.2243140
pubmed: 23372086
Cho, K.-A. et al. Portable, non-invasive video imaging of retinal blood flow dynamics. Sci. Rep. 10, 20236 (2020).
doi: 10.1038/s41598-020-76407-5
pubmed: 33214571
pmcid: 7677377
Vinnett, A. et al. Dynamic alterations in blood flow in glaucoma measured with laser speckle contrast imaging. Ophthalmol. Glaucoma 5, 250–261 (2022).
doi: 10.1016/j.ogla.2021.10.005
pubmed: 34673279
Balasubramanian, T. et al. Neonatal vital signs using noncontact laser speckle contrast imaging compared to standard care in retinopathy of prematurity screening. J. Am. Assoc. Pediatr. Ophthalmol. Strabismus 26, e38–e39 (2022).
doi: 10.1016/j.jaapos.2022.08.144
Ozcan, P. Y. et al. Assessment of orbital blood flow velocities in retinopathy of prematurity. Int. Ophthalmol. 37, 795–799 (2017).
doi: 10.1007/s10792-016-0333-1
pubmed: 27591784
Matsumoto, T. et al. Ocular blood flow values measured by laser speckle flowgraphy correlate with the postmenstrual age of normal neonates. Graefes Arch. Clin. Exp. Ophthalmol. 254, 1631–1636 (2016).
doi: 10.1007/s00417-016-3362-6
pubmed: 27118037
pmcid: 4961725
Silverman, R. H. et al. Ocular blood flow in preterm neonates: A preliminary report. Transl. Vis. Sci. Technol. 10, 22 (2021).
doi: 10.1167/tvst.10.2.22
pubmed: 34003907
pmcid: 7900851
Hartenstein, S., Müller, B., Metze, B., Czernik, C. & Bührer, C. Blood flow assessed by color Doppler imaging in retinopathy of prematurity. J. Perinatol. 35, 745–747 (2015).
doi: 10.1038/jp.2015.45
pubmed: 25950917
Papacci, P. et al. Doppler ultrasound of blood flow velocities in ophthalmic and central retinal arteries during the early neonatal period. Am. J. Ophthalmol. 126, 691–697 (1998).
doi: 10.1016/S0002-9394(98)00203-7
pubmed: 9822233
Romagnoli, C. et al. Normal neonatal values of ophthalmic and central retinal artery blood flow velocities. J. Pediatr. Ophthalmol. Strabismus 38, 213–217 (2001).
doi: 10.3928/0191-3913-20010701-07
pubmed: 11495308
Zhou, K. et al. Quantitative handheld swept-source optical coherence tomography angiography in awake preterm and full-term infants. Transl. Vis. Sci. Technol. 9, 19 (2020).
doi: 10.1167/tvst.9.13.19
pubmed: 33344063
pmcid: 7735945
Vural, A., Gunay, M., Celik, G., Demirayak, B. & Kizilay, O. Comparison of foveal optical coherence tomography angiography findings between premature children with ROP and non-premature healthy children. Eye Lond. Engl. 35, 1721–1729 (2021).
Matsumoto, T. et al. Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report. Graefes Arch. Clin. Exp. Ophthalmol. 256, 2241–2247 (2018).
doi: 10.1007/s00417-018-4063-0
pubmed: 29980917
Matsumoto, T. et al. Decreased ocular blood flow after photocoagulation therapy in neonatal retinopathy of prematurity. Jpn. J. Ophthalmol. 61, 484–493 (2017).
doi: 10.1007/s10384-017-0536-7
pubmed: 28932922
Fierson, W. M. et al. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 142, e20183061 (2018).
doi: 10.1542/peds.2018-3061
pubmed: 30478242
Miao, P., Rege, A., Li, N., Thakor, N. V. & Tong, S. High resolution cerebral blood flow imaging by registered laser speckle contrast analysis. IEEE Trans. Biomed. Eng. 57, 1152–1157 (2010).
doi: 10.1109/TBME.2009.2037434
pubmed: 20142159
Zepeda-Romero, L. C. et al. Early retinopathy of prematurity findings identified with fluorescein angiography. Graefes Arch. Clin. Exp. Ophthalmol. 251, 2093–2097 (2013).
doi: 10.1007/s00417-013-2321-8
pubmed: 23546400
Mangalesh, S. et al. Preterm infant stress during handheld optical coherence tomography vs binocular indirect ophthalmoscopy examination for retinopathy of prematurity. JAMA Ophthalmol. 139, 567–574 (2021).
doi: 10.1001/jamaophthalmol.2021.0377
pubmed: 33792625
Mataftsi, A. et al. Optical coherence tomography angiography in children with spontaneously regressed retinopathy of prematurity. Eye Lond. Engl. 35, 1411–1417 (2021).
Vinekar, A., Sinha, S., Mangalesh, S., Jayadev, C. & Shetty, B. Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 259, 2131–2137 (2021).
doi: 10.1007/s00417-021-05090-7
pubmed: 33547964
Bowl, W. et al. OCT angiography in young children with a history of retinopathy of prematurity. Ophthalmol. Retina 2, 972–978 (2018).
doi: 10.1016/j.oret.2018.02.004
pubmed: 31047230
Niwald, A. & Grałek, M. Evaluation of blood flow in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity. Klin. Ocz. 108, 32–35 (2006).
Campbell, J. P. et al. Handheld optical coherence tomography angiography and ultra-wide-field optical coherence tomography in retinopathy of prematurity. JAMA Ophthalmol. 135, 977–981 (2017).
doi: 10.1001/jamaophthalmol.2017.2481
pubmed: 28750113
pmcid: 6583755
Fadakar, K. et al. Validation of the postnatal growth and retinopathy of prematurity (GROP) screening criteria. Med. Hypothesis Discov. Innov. Ophthalmol. 11, 77–84 (2022).
doi: 10.51329/mehdiophthal1449
pubmed: 37641787
pmcid: 10445302
Kalarn, S. et al. Repeatability and reproducibility of the XyCAM RI across multiple operators. Invest. Ophthalmol. Vis. Sci. 61, 5321 (2020).