Different ER-plasma membrane tethers play opposing roles in autophagy of the cortical ER.
autophagy
endoplasmic reticulum
lipid transfer
membrane tether
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 Jun 2024
11 Jun 2024
Historique:
medline:
5
6
2024
pubmed:
5
6
2024
entrez:
5
6
2024
Statut:
ppublish
Résumé
The endoplasmic reticulum (ER) undergoes degradation by selective macroautophagy (ER-phagy) in response to starvation or the accumulation of misfolded proteins within its lumen. In yeast, actin assembly at sites of contact between the cortical ER (cER) and endocytic pits acts to displace elements of the ER from their association with the plasma membrane (PM) so they can interact with the autophagosome assembly machinery near the vacuole. A collection of proteins tether the cER to the PM. Of these, Scs2/22 and Ist2 are required for cER-phagy, most likely through their roles in lipid transport, while deletion of the tricalbins,
Identifiants
pubmed: 38838012
doi: 10.1073/pnas.2321991121
doi:
Substances chimiques
Saccharomyces cerevisiae Proteins
0
Membrane Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2321991121Subventions
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM35370
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM131681
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.