Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.

Animals Glucagon-Like Peptide-1 Receptor / metabolism Mice Mice, Inbred C57BL Islets of Langerhans Transplantation T-Lymphocytes / immunology Male Heart Transplantation Mice, Inbred BALB C CD8-Positive T-Lymphocytes / metabolism Graft Survival / immunology
GLP-1R GLP-1R agonists GLP-1R signaling alloimmunity cancer immune checkpoint

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
04 Jun 2024
Historique:
received: 27 07 2023
revised: 06 12 2023
accepted: 02 05 2024
medline: 6 6 2024
pubmed: 6 6 2024
entrez: 5 6 2024
Statut: ppublish

Résumé

Glucagon-like peptide-1 receptor (GLP-1R) is a key regulator of glucose metabolism known to be expressed by pancreatic β cells. We herein investigated the role of GLP-1R on T lymphocytes during immune response. Our data showed that a subset of T lymphocytes expresses GLP-1R, which is upregulated during alloimmune response, similarly to PD-1. When mice received islet or cardiac allotransplantation, an expansion of GLP-1R

Identifiants

DOI: 10.1016/j.cmet.2024.05.001 PMID: 38838642
pubmed: 38838642
pii: S1550-4131(24)00177-3
doi: 10.1016/j.cmet.2024.05.001
pii:
doi:

Substances chimiques

Glucagon-Like Peptide-1 Receptor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1302-1319.e12

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Moufida Ben Nasr (M)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy; Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Vera Usuelli (V)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Sergio Dellepiane (S)

Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Andy Joe Seelam (AJ)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Teresa Vanessa Fiorentino (TV)

Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.

Francesca D'Addio (F)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Emma Fiorina (E)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Cong Xu (C)

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science, Wuhan, China.

Yanan Xie (Y)

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science, Wuhan, China.

Hari Baskar Balasubramanian (HB)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Eduardo Castillo-Leon (E)

Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Lara Loreggian (L)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Anna Maestroni (A)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Emma Assi (E)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Cristian Loretelli (C)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Ahmed Abdelsalam (A)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Basset El Essawy (B)

Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Medicine, Al-Azhar University, Cairo, Egypt.

Silvia Uccella (S)

Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy.

Ida Pastore (I)

Division of Endocrinology, ASST Fatebenefratelli Sacco, Milan, Italy.

Maria Elena Lunati (ME)

Division of Endocrinology, ASST Fatebenefratelli Sacco, Milan, Italy.

Gianmarco Sabiu (G)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy; Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Adriana Petrazzuolo (A)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy.

Giacomo Ducci (G)

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy; Department of Health Sciences, Universita'degli Studi di Milano, Milan, Italy.

Elena Sacco (E)

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy; Department of Health Sciences, Universita'degli Studi di Milano, Milan, Italy.

Lucia Centofanti (L)

Department of Health Sciences, Universita'degli Studi di Milano, Milan, Italy.

Massimo Venturini (M)

University of Insubria, Varese, Italy.

Serena Mazzucchelli (S)

Nanomedicine Laboratory, DIBIC, Università di Milano, Milan, Italy.

Deborah Mattinzoli (D)

Nephrology, dialysis and renal transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Masami Ikehata (M)

Nephrology, dialysis and renal transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Giuseppe Castellano (G)

Nephrology, dialysis and renal transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Gary Visner (G)

Pulmonary Medicine, Boston Children's Hospital/Harvard Medical School, Boston, MA, USA.

Liu Kaifeng (L)

Pulmonary Medicine, Boston Children's Hospital/Harvard Medical School, Boston, MA, USA.

Kang Mi Lee (KM)

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Zhimin Wang (Z)

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Domenico Corradi (D)

Department of Biomedical, Biotechnological and Translational Sciences, Unit of Pathology, University of Parma, Parma, Italy.

Stefano La Rosa (S)

Unit of Pathology, Department of Medicine and Technological innovation, University of Insubria, Varese, Italy; Unit of Pathology, Department of Oncology, ASST Sette Laghi, Varese, Italy.

Silvio Danese (S)

Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele, Milan, Italy.

Jun Yang (J)

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science, Wuhan, China.

James F Markmann (JF)

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Gian Vincenzo Zuccotti (GV)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy; Department of Pediatrics, Children's Hospital Buzzi, University of Milan, Milan, Italy.

Reza Abdi (R)

Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Franco Folli (F)

Department of Health Sciences, Universita'degli Studi di Milano, Milan, Italy. Electronic address: franco.folli@unimi.it.

Paolo Fiorina (P)

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC, Università di Milano, Milan, Italy; Nephrology Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, ASST Fatebenefratelli Sacco, Milan, Italy. Electronic address: paolo.fiorina@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone gastrointestinale › Récepteurs des peptides similaires au glucagon › Récepteur du peptide-1 similaire au glucagon › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation d'ilots de Langerhans › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Transplantation cardiaque › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Glucagon-like peptide 1 receptor is a T...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Glucagon-like peptide 1 receptor is a T...