Cellular architecture shapes the naïve T cell response.

CD8-Positive T-Lymphocytes / immunology Animals Mice Cell Differentiation Receptors, Antigen, T-Cell / immunology Nuclear Receptor Subfamily 4, Group A, Member 1 / genetics Lymphocyte Activation Nuclear Envelope / metabolism Calcium / metabolism Immunologic Memory Mice, Inbred C57BL

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
07 Jun 2024
Historique:
medline: 6 6 2024
pubmed: 6 6 2024
entrez: 6 6 2024
Statut: ppublish

Résumé

After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic predeterminants controlling these single-cell decisions remain enigmatic. We found that the subcellular architectures of naïve CD8 T cells, defined by the presence (T

Identifiants

DOI: 10.1126/science.adh8967 PMID: 38843327
pubmed: 38843327
doi: 10.1126/science.adh8967
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Nuclear Receptor Subfamily 4, Group A, Member 1 0
Nr4a1 protein, mouse 0
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadh8697

Auteurs

Benjamin D Hale (BD)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0002-5095-8124

Yannik Severin (Y)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0003-4482-6237

Fabienne Graebnitz (F)

Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0002-5145-3662

Dominique Stark (D)

Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0002-3214-7950

Daniel Guignard (D)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0009-0001-4937-1414

Julien Mena (J)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0001-8040-810X

Yasmin Festl (Y)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.

Sohyon Lee (S)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0003-4790-4990

Jacob Hanimann (J)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0003-3156-0441

Nathan S Zangger (NS)

Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0003-1130-1899

Michelle Meier (M)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0009-0005-5595-3882

David Goslings (D)

Blood Transfusion Service Zürich, Swiss Red Cross (SRC), Schlieren, Switzerland.

Olga Lamprecht (O)

Blood Transfusion Service Zürich, Swiss Red Cross (SRC), Schlieren, Switzerland.
ORCID: 0000-0002-8003-2429

Beat M Frey (BM)

Blood Transfusion Service Zürich, Swiss Red Cross (SRC), Schlieren, Switzerland.
ORCID: 0000-0002-2514-8621

Annette Oxenius (A)

Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
ORCID: 0000-0002-2079-2354

Berend Snijder (B)

Institute of Molecular Systems Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Comprehensive Cancer Center Zurich (CCCZ), Zürich, Switzerland.
ORCID: 0000-0003-3386-6583

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Eucaryotes › Animaux › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-1 du groupe A de la sous-famille-4 de récepteurs nucléaires › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Membranes intracellulaires › Enveloppe nucléaire › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Cellular architecture shapes the naïve T cell response.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cellular architecture shapes the naïve T cell response.