Pathophysiology of Cardiac Amyloidosis.

Humans Amyloidosis / physiopathology Cardiomyopathies / physiopathology Heart Failure / physiopathology Oxidative Stress Myocardium / pathology
Amyloid cardiomyopathy Cardiac amyloidosis Misfolded proteins Pathophysiology

Journal

Heart failure clinics
ISSN: 1551-7136
Titre abrégé: Heart Fail Clin
Pays: United States
ID NLM: 101231934

Informations de publication

Date de publication:
Jul 2024
Historique:
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 6 6 2024
Statut: ppublish

Résumé

Amyloidosis refers to a heterogeneous group of disorders sharing common pathophysiological mechanisms characterized by the extracellular accumulation of fibrillar deposits consisting of the aggregation of misfolded proteins. Cardiac amyloidosis (CA), usually caused by deposition of misfolded transthyretin or immunoglobulin light chains, is an increasingly recognized cause of heart failure burdened by a poor prognosis. CA manifests with a restrictive cardiomyopathy which progressively leads to biventricular thickening, diastolic and then systolic dysfunction, arrhythmias, and valvular disease. The pathophysiology of CA is multifactorial and includes increased oxidative stress, mitochondrial damage, apoptosis, impaired metabolism, and modifications of intracellular calcium balance.

Identifiants

DOI: 10.1016/j.hfc.2024.02.002 PMID: 38844297
pubmed: 38844297
pii: S1551-7136(24)00016-3
doi: 10.1016/j.hfc.2024.02.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

261-270

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Paolo Morfino (P)

Scuola Superiore Sant'Anna, Pisa, Italy.

Alberto Aimo (A)

Fondazione Toscana Gabriele Monasterio, via G. Moruzzi 1, 56124, Pisa, Italy; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy.

Maria Franzini (M)

Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.

Giuseppe Vergaro (G)

Fondazione Toscana Gabriele Monasterio, via G. Moruzzi 1, 56124, Pisa, Italy; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy.

Vincenzo Castiglione (V)

Fondazione Toscana Gabriele Monasterio, via G. Moruzzi 1, 56124, Pisa, Italy; Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy.

Giorgia Panichella (G)

Department of Clinical and Experimental Medicine, Careggi University Hospital, Florence, Italy.

Giuseppe Limongelli (G)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Michele Emdin (M)

Scuola Superiore Sant'Anna, Pisa, Italy; Fondazione Toscana Gabriele Monasterio, via G. Moruzzi 1, 56124, Pisa, Italy. Electronic address: m.emdin@santannapisa.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pathophysiology of Cardiac Amyloidosis.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Amyloïdose › Pathophysiology of Cardiac Amyloidosis.
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Pathophysiology of Cardiac Amyloidosis.
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Pathophysiology of Cardiac Amyloidosis.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Pathophysiology of Cardiac Amyloidosis.
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Pathophysiology of Cardiac Amyloidosis.