The Role of Scintigraphy with Bone Radiotracers in Cardiac Amyloidosis.

Humans Cardiomyopathies / diagnostic imaging Amyloidosis / diagnostic imaging Radiopharmaceuticals Radionuclide Imaging / methods Bone and Bones / diagnostic imaging Myocardium / pathology Amyloid Neuropathies, Familial / diagnostic imaging Heart Failure / diagnostic imaging Prealbumin / metabolism
Cardiac amyloidosis Cardiac imaging Diagnosis Scintigraphy

Journal

Heart failure clinics
ISSN: 1551-7136
Titre abrégé: Heart Fail Clin
Pays: United States
ID NLM: 101231934

Informations de publication

Date de publication:
Jul 2024
Historique:
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 6 6 2024
Statut: ppublish

Résumé

Cardiac amyloidosis (CA) is caused by the myocardial deposition of misfolded proteins, either amyloid transthyretin (ATTR) or immunoglobulin light chains (AL). The paradigm of this condition has transformed, since CA is increasingly recognized as a relatively prevalent cause of heart failure. Cardiac scintigraphy with bone tracers is the unique noninvasive technique able to confirm CA without performing tissue biopsy or advanced imaging tests. A moderate-to-intense myocardial uptake (Perugini grade ≥2) associated with the absence of a monoclonal component is greater than 99% specific for ATTR-CA, while AL-CA confirmation requires tissue biopsy.

Identifiants

DOI: 10.1016/j.hfc.2024.03.003 PMID: 38844301
pubmed: 38844301
pii: S1551-7136(24)00019-9
doi: 10.1016/j.hfc.2024.03.003
pii:
doi:

Substances chimiques

Radiopharmaceuticals 0
Prealbumin 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

307-316

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure None. Funding: none.

Auteurs

Paolo Morfino (P)

Department of Cardiology, Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy.

Alberto Aimo (A)

Department of Cardiology, Fondazione Toscana Gabriele Monasterio; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy.

Assuero Giorgetti (A)

Nuclear Medicine Division, Fondazione Toscana Gabriele Monasterio, via Moruzzi 1, Pisa 56124, Italy.

Dario Genovesi (D)

Nuclear Medicine Division, Fondazione Toscana Gabriele Monasterio, via Moruzzi 1, Pisa 56124, Italy.

Marco Merlo (M)

Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI) and University of Trieste, Via P. Valdoni 7, Trieste 34100, Italy; European Reference Network for Rare Low Prevalence and Complex Diseases of the Heart-ERN GUARD Heart Via P. Valdoni 7 Trieste 34100, Italy.

Giuseppe Limongelli (G)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", via Leonardo Bianchi, Naples 80131, Italy.

Vincenzo Castiglione (V)

Department of Cardiology, Fondazione Toscana Gabriele Monasterio; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy.

Giuseppe Vergaro (G)

Department of Cardiology, Fondazione Toscana Gabriele Monasterio; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy.

Michele Emdin (M)

Cardiovascular Diseases, Health Science Interdisciplinary Center, Scuola Superiore Sant'Anna, Pisa, Italy; Cardio-thoracic Department, Fondazione Toscana Gabriele Monasterio, Via G. Moruzzi 1, Pisa 56124, Italy. Electronic address: m.emdin@santannapisa.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Amyloïdose › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Amyloïdose › Amyloïdose familiale › Neuropathies amyloïdes familiales › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › The Role of Scintigraphy with Bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Préalbumine › The Role of Scintigraphy with Bone...