Somatic mutations associate with clonal expansion of CD8

Humans CD8-Positive T-Lymphocytes / immunology Mutation Receptors, Antigen, T-Cell / genetics Adult Single-Cell Analysis Male Female Middle Aged CD4-Positive T-Lymphocytes / immunology Gene Frequency Phenotype Aged

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
07 Jun 2024
Historique:
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 7 6 2024
Statut: ppublish

Résumé

Somatic mutations in T cells can cause cancer but also have implications for immunological diseases and cell therapies. The mutation spectrum in nonmalignant T cells is unclear. Here, we examined somatic mutations in CD4

Identifiants

DOI: 10.1126/sciadv.adj0787 PMID: 38848368
pubmed: 38848368
doi: 10.1126/sciadv.adj0787
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj0787

Auteurs

Sofie Lundgren (S)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0003-3146-9816

Mikko Myllymäki (M)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.

Timo Järvinen (T)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0001-5316-5472

Mikko A I Keränen (MAI)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
ORCID: 0000-0001-8027-499X

Jason Theodoropoulos (J)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-2399-658X

Johannes Smolander (J)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0003-3872-9668

Daehong Kim (D)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-1253-8946

Urpu Salmenniemi (U)

Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Stem Cell Transplantation Unit, Turku University Hospital, Turku, Finland.
ORCID: 0009-0002-2053-3384

Gunilla Walldin (G)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0009-0005-6663-6540

Paula Savola (P)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Department of Clinical Chemistry, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Tiina Kelkka (T)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0003-1085-6382

Hanna Rajala (H)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
ORCID: 0000-0003-2675-2385

Eva Hellström-Lindberg (E)

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0000-0002-7839-3743

Maija Itälä-Remes (M)

Stem Cell Transplantation Unit, Turku University Hospital, Turku, Finland.

Matti Kankainen (M)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-4714-9481

Satu Mustjoki (S)

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
ICAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.
ORCID: 0000-0002-0816-8241

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Somatic mutations associate with clonal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Somatic mutations associate with clonal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Somatic mutations associate with clonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Somatic mutations associate with clonal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Somatic mutations associate with clonal...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Somatic mutations associate with clonal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Somatic mutations associate with clonal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Somatic mutations associate with clonal...
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › Somatic mutations associate with clonal...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Somatic mutations associate with clonal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Somatic mutations associate with clonal...