Systematic assessment of long-read RNA-seq methods for transcript identification and quantification.


Journal

Nature methods
ISSN: 1548-7105
Titre abrégé: Nat Methods
Pays: United States
ID NLM: 101215604

Informations de publication

Date de publication:
07 Jun 2024
Historique:
received: 02 08 2021
accepted: 03 05 2024
medline: 8 6 2024
pubmed: 8 6 2024
entrez: 7 6 2024
Statut: aheadofprint

Résumé

The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platforms, the consortium generated over 427 million long-read sequences from complementary DNA and direct RNA datasets, encompassing human, mouse and manatee species. Developers utilized these data to address challenges in transcript isoform detection, quantification and de novo transcript detection. The study revealed that libraries with longer, more accurate sequences produce more accurate transcripts than those with increased read depth, whereas greater read depth improved quantification accuracy. In well-annotated genomes, tools based on reference sequences demonstrated the best performance. Incorporating additional orthogonal data and replicate samples is advised when aiming to detect rare and novel transcripts or using reference-free approaches. This collaborative study offers a benchmark for current practices and provides direction for future method development in transcriptome analysis.

Identifiants

pubmed: 38849569
doi: 10.1038/s41592-024-02298-3
pii: 10.1038/s41592-024-02298-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM138122
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM14264
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01HG008759
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01HG011469
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01GM136886
Organisme : NHGRI NIH HHS
ID : UM1 HG009443
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01HG008759
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01HG011469
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01GM136886
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : F31HG010999
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : NHGRI NIH HHS
ID : UM1 HG009443
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01HG008759
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01HG011469
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : R01GM136886
Organisme : NHGRI NIH HHS
ID : UM1 HG009443
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : U41HG007234
Organisme : Saint Petersburg State University (St. Petersburg State University)
ID : 73023672
Organisme : Wellcome Trust (Wellcome)
ID : WT108749/Z/15/Z

Informations de copyright

© 2024. The Author(s).

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Auteurs

Francisco J Pardo-Palacios (FJ)

Institute for Integrative Systems Biology, Spanish National Research Council (CSIC), Paterna, Spain.

Dingjie Wang (D)

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Fairlie Reese (F)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.
Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.

Mark Diekhans (M)

UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.

Sílvia Carbonell-Sala (S)

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Brian Williams (B)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Jane E Loveland (JE)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Maite De María (M)

Department of Physiological Sciences, College of Veterinary Medicine, Gainesville, FL, USA.
Cherokee Nation System Solutions, contractor to the US Geological Survey-Wetland and Aquatic Research Center, Gainesville, FL, USA.

Matthew S Adams (MS)

Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.

Gabriela Balderrama-Gutierrez (G)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.
Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.

Amit K Behera (AK)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.

Jose M Gonzalez Martinez (JM)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Toby Hunt (T)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Julien Lagarde (J)

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Flomics Biotech, SL, Barcelona, Spain.

Cindy E Liang (CE)

Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA.

Haoran Li (H)

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Marcus Jerryd Meade (MJ)

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.

David A Moraga Amador (DA)

Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA.

Andrey D Prjibelski (AD)

Department of Computer Science, University of Helsinki, Helsinki, Finland.
Center for Bioinformatics and Algorithmic Biotechnology, Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.

Inanc Birol (I)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Hamed Bostan (H)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.

Ashley M Brooks (AM)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.

Muhammed Hasan Çelik (MH)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.
Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.

Ying Chen (Y)

Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Mei R M Du (MRM)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Colette Felton (C)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.

Jonathan Göke (J)

Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Department of Statistics and Data Science, National University of Singapore, Singapore, Singapore.

Saber Hafezqorani (S)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Ralf Herwig (R)

Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.

Hideya Kawaji (H)

Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Joseph Lee (J)

Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Jian-Liang Li (JL)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.

Matthias Lienhard (M)

Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.

Alla Mikheenko (A)

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.

Dennis Mulligan (D)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.

Ka Ming Nip (KM)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

Mihaela Pertea (M)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.

Matthew E Ritchie (ME)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.

Andre D Sim (AD)

Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Alison D Tang (AD)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.

Yuk Kei Wan (YK)

Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Changqing Wang (C)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Brandon Y Wong (BY)

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.

Chen Yang (C)

Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.

If Barnes (I)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Andrew E Berry (AE)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Salvador Capella-Gutierrez (S)

Barcelona Supercomputing Center, Barcelona, Spain.

Alyssa Cousineau (A)

Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Namrita Dhillon (N)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.

Jose M Fernandez-Gonzalez (JM)

Barcelona Supercomputing Center, Barcelona, Spain.

Luis Ferrández-Peral (L)

Institute for Integrative Systems Biology, Spanish National Research Council (CSIC), Paterna, Spain.

Natàlia Garcia-Reyero (N)

Energy, Installations & Environment, Office of the Assistant Secretary of Defense, Washington, DC, USA.

Stefan Götz (S)

Biobam Bioinformatics, Valencia, Spain.

Carles Hernández-Ferrer (C)

Barcelona Supercomputing Center, Barcelona, Spain.

Liudmyla Kondratova (L)

Genetics Institute, University of Florida, Gainesville, FL, USA.

Tianyuan Liu (T)

Cardiff University, Cardiff, UK.

Alessandra Martinez-Martin (A)

Institute for Integrative Systems Biology, Spanish National Research Council (CSIC), Paterna, Spain.

Carlos Menor (C)

Biobam Bioinformatics, Valencia, Spain.

Jorge Mestre-Tomás (J)

Institute for Integrative Systems Biology, Spanish National Research Council (CSIC), Paterna, Spain.

Jonathan M Mudge (JM)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Nedka G Panayotova (NG)

Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA.

Alejandro Paniagua (A)

Institute for Integrative Systems Biology, Spanish National Research Council (CSIC), Paterna, Spain.

Dmitry Repchevsky (D)

Barcelona Supercomputing Center, Barcelona, Spain.

Xingjie Ren (X)

Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.

Eric Rouchka (E)

Department of Biochemistry & Molecular Genetics, University of Louisville, Louisville, KY, USA.

Brandon Saint-John (B)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.

Enrique Sapena (E)

European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

Leon Sheynkman (L)

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.

Melissa Laird Smith (ML)

Department of Biochemistry & Molecular Genetics, University of Louisville, Louisville, KY, USA.

Marie-Marthe Suner (MM)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK.

Hazuki Takahashi (H)

Center for Integrative Medical Sciences, Laboratory for Transcriptome Technology, RIKEN, Yokohama, Japan.

Ingrid A Youngworth (IA)

Department of Genetics, Stanford University, Palo Alto, CA, USA.

Piero Carninci (P)

Center for Integrative Medical Sciences, Laboratory for Transcriptome Technology, RIKEN, Yokohama, Japan.
Human Technopole, Milano, Italy.

Nancy D Denslow (ND)

Department of Physiological Sciences, College of Veterinary Medicine, Gainesville, FL, USA.
Center for Environmental and Human Toxicology, Department of Physiological Sciences, University of Florida, Gainesville, FL, USA.

Roderic Guigó (R)

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Margaret E Hunter (ME)

US Geological Survey, Wetland and Aquatic Research Center, Gainesville, FL, USA.

Rene Maehr (R)

Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Yin Shen (Y)

Institute for Human Genetics, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Hagen U Tilgner (HU)

Brain and Mind Research Institute and Center for Neurogenetics, Weill Cornell Medicine, New York City, NY, USA.

Barbara J Wold (BJ)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Christopher Vollmers (C)

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA. vollmers@ucsc.edu.

Adam Frankish (A)

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus Hinxton, Cambridge, UK. frankish@ebi.ac.uk.

Kin Fai Au (KF)

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA. kinfai@med.umich.edu.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. kinfai@med.umich.edu.

Gloria M Sheynkman (GM)

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. gs9yr@virginia.edu.
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. gs9yr@virginia.edu.
UVA Cancer Center, University of Virginia, Charlottesville, VA, USA. gs9yr@virginia.edu.

Ali Mortazavi (A)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA. ali.mortazavi@uci.edu.
Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA. ali.mortazavi@uci.edu.

Ana Conesa (A)

Institute for Integrative Systems Biology, Spanish National Research Council (CSIC), Paterna, Spain. ana.conesa@csic.es.
Microbiology and Cell Science Department, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA. ana.conesa@csic.es.

Angela N Brooks (AN)

UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA. anbrooks@ucsc.edu.
Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA. anbrooks@ucsc.edu.

Classifications MeSH