Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.
Humans
Norway
Female
Male
Phenotype
Child, Preschool
Cohort Studies
Neurodevelopmental Disorders
/ genetics
Mothers
Autistic Disorder
/ genetics
Genetic Predisposition to Disease
Adult
Fathers
Genome-Wide Association Study
Attention Deficit Disorder with Hyperactivity
/ genetics
Schizophrenia
/ genetics
Genetic Heterogeneity
Journal
Molecular autism
ISSN: 2040-2392
Titre abrégé: Mol Autism
Pays: England
ID NLM: 101534222
Informations de publication
Date de publication:
07 Jun 2024
07 Jun 2024
Historique:
received:
22
11
2023
accepted:
18
04
2024
medline:
8
6
2024
pubmed:
8
6
2024
entrez:
7
6
2024
Statut:
epublish
Résumé
Autism and different neurodevelopmental conditions frequently co-occur, as do their symptoms at sub-diagnostic threshold levels. Overlapping traits and shared genetic liability are potential explanations. In the population-based Norwegian Mother, Father, and Child Cohort study (MoBa), we leverage item-level data to explore the phenotypic factor structure and genetic architecture underlying neurodevelopmental traits at age 3 years (N = 41,708-58,630) using maternal reports on 76 items assessing children's motor and language development, social functioning, communication, attention, activity regulation, and flexibility of behaviors and interests. We identified 11 latent factors at the phenotypic level. These factors showed associations with diagnoses of autism and other neurodevelopmental conditions. Most shared genetic liabilities with autism, ADHD, and/or schizophrenia. Item-level GWAS revealed trait-specific genetic correlations with autism (items r These exploratory findings emphasize the etiological complexity of neurodevelopmental traits at this early age. In particular, diverse associations with neurodevelopmental conditions and genetic heterogeneity could inform follow-up work to identify shared and differentiating factors in the early manifestations of neurodevelopmental traits and their relation to autism and other neurodevelopmental conditions. This in turn could have implications for clinical screening tools and programs.
Sections du résumé
BACKGROUND
BACKGROUND
Autism and different neurodevelopmental conditions frequently co-occur, as do their symptoms at sub-diagnostic threshold levels. Overlapping traits and shared genetic liability are potential explanations.
METHODS
METHODS
In the population-based Norwegian Mother, Father, and Child Cohort study (MoBa), we leverage item-level data to explore the phenotypic factor structure and genetic architecture underlying neurodevelopmental traits at age 3 years (N = 41,708-58,630) using maternal reports on 76 items assessing children's motor and language development, social functioning, communication, attention, activity regulation, and flexibility of behaviors and interests.
RESULTS
RESULTS
We identified 11 latent factors at the phenotypic level. These factors showed associations with diagnoses of autism and other neurodevelopmental conditions. Most shared genetic liabilities with autism, ADHD, and/or schizophrenia. Item-level GWAS revealed trait-specific genetic correlations with autism (items r
CONCLUSIONS
CONCLUSIONS
These exploratory findings emphasize the etiological complexity of neurodevelopmental traits at this early age. In particular, diverse associations with neurodevelopmental conditions and genetic heterogeneity could inform follow-up work to identify shared and differentiating factors in the early manifestations of neurodevelopmental traits and their relation to autism and other neurodevelopmental conditions. This in turn could have implications for clinical screening tools and programs.
Identifiants
pubmed: 38849897
doi: 10.1186/s13229-024-00599-0
pii: 10.1186/s13229-024-00599-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25Subventions
Organisme : Helse Sør-Øst RHF
ID : 2020022
Organisme : Helse Sør-Øst RHF
ID : 2021045
Organisme : Helse Sør-Øst RHF
ID : 2020023
Organisme : Helse Sør-Øst RHF
ID : 2019097
Organisme : Norges Forskningsråd
ID : 274611
Organisme : Norges Forskningsråd
ID : 324620
Organisme : Simons Foundation Autism Research Initiative
ID : 724306
Informations de copyright
© 2024. The Author(s).
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