LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 Jun 2024
08 Jun 2024
Historique:
received:
24
01
2024
accepted:
27
05
2024
medline:
9
6
2024
pubmed:
9
6
2024
entrez:
8
6
2024
Statut:
epublish
Résumé
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.
Identifiants
pubmed: 38851803
doi: 10.1038/s41467-024-49301-1
pii: 10.1038/s41467-024-49301-1
doi:
Substances chimiques
Receptors, LDL
0
Antiviral Agents
0
Receptors, Virus
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4906Informations de copyright
© 2024. The Author(s).
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