Development of methyl 5-((cinnamoyloxy)methyl)picolinate, exploring its bio-target potential aiming at CVD mediated by multiple proteins through surface and physiochemical analysis.
Cardiovascular diseases
Cinnamic acid
Density functional theory
Molecular docking
Swiss ADME
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 06 2024
10 06 2024
Historique:
received:
03
03
2024
accepted:
05
06
2024
medline:
11
6
2024
pubmed:
11
6
2024
entrez:
10
6
2024
Statut:
epublish
Résumé
The emphasis on sustainable sources of drug development seems imminent with phytochemicals emerging as promising candidates due to their minimal probability of adverse effects. This study focuses on utilizing simple cinnamic acid and nicotinic acid derivatives as starting materials, employing an efficient synthetic protocol to obtain methyl 5-((cinnamoyloxy)methyl)picolinate targeting CVD mediated by multiple enzymes such as MAPK, PCSK9, MPO, SIRT1 and TNF-α. Comprehensive characterization of synthesized molecule is achieved through
Identifiants
pubmed: 38858562
doi: 10.1038/s41598-024-64165-7
pii: 10.1038/s41598-024-64165-7
doi:
Substances chimiques
Picolinic Acids
0
Cinnamates
0
cinnamic acid
140-10-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13328Informations de copyright
© 2024. The Author(s).
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