First incidence of extrarenal wilms tumor within the spinal canal in the adult population: a novel case report and literature review.
Extra-renal nephroblastoma
Extrarenal Wilms tumor
Nephroblastoma
Spinal dysraphism
Spinal tumors
Wilms tumor
Journal
BMC urology
ISSN: 1471-2490
Titre abrégé: BMC Urol
Pays: England
ID NLM: 100968571
Informations de publication
Date de publication:
10 Jun 2024
10 Jun 2024
Historique:
received:
09
04
2024
accepted:
04
06
2024
medline:
11
6
2024
pubmed:
11
6
2024
entrez:
10
6
2024
Statut:
epublish
Résumé
Wilms tumor (WT), also known as nephroblastoma, is rare in adults, accounting for merely 3% of all nephroblastomas or 0.2 cases per million individuals. Extrarenal Wilms tumor (ERWT) emerges outside the renal boundaries and comprises 0.5 to 1% of all WT cases, with even rarer incidences in adults. Oncogenic mutations associated with ectopic nephrogenic rests (NR) may contribute to ERWT development. Diagnosis involves surgical resection and pathology examination. Due to scarce cases, adults often rely on pediatric guidelines. We thoroughly searched PubMed, Scopus, and Web of Science databases to establish our case's uniqueness. To the best of our knowledge, this is the first documented incidence of extrarenal Wilms tumor within the spinal canal in the adult population. A 22-year-old woman with a history of congenital lipo-myelomeningocele surgery as an infant presented with a 6-month history of back pain. This pain gradually resulted in limb weakness, paraparesis, and loss of bladder and bowel control. An MRI showed a 6 × 5 × 3 cm spinal canal mass at the L4-S1 level. Consequently, a laminectomy was performed at the L4-L5 level to remove the intramedullary tumor. Post-surgery histopathology and immunohistochemistry confirmed the tumor as ERWT with favorable histology without any teratomatous component. This report underscores the rarity of extrarenal Wilms tumor (ERWT) in adults, challenging conventional assumptions about its typical age of occurrence. It emphasizes the importance of clinical awareness regarding such uncommon cases. Moreover, the co-occurrence of spinal ERWTs and a history of spinal anomalies warrants further investigation.
Sections du résumé
BACKGROUND
BACKGROUND
Wilms tumor (WT), also known as nephroblastoma, is rare in adults, accounting for merely 3% of all nephroblastomas or 0.2 cases per million individuals. Extrarenal Wilms tumor (ERWT) emerges outside the renal boundaries and comprises 0.5 to 1% of all WT cases, with even rarer incidences in adults. Oncogenic mutations associated with ectopic nephrogenic rests (NR) may contribute to ERWT development. Diagnosis involves surgical resection and pathology examination. Due to scarce cases, adults often rely on pediatric guidelines. We thoroughly searched PubMed, Scopus, and Web of Science databases to establish our case's uniqueness. To the best of our knowledge, this is the first documented incidence of extrarenal Wilms tumor within the spinal canal in the adult population.
CASE PRESENTATION
METHODS
A 22-year-old woman with a history of congenital lipo-myelomeningocele surgery as an infant presented with a 6-month history of back pain. This pain gradually resulted in limb weakness, paraparesis, and loss of bladder and bowel control. An MRI showed a 6 × 5 × 3 cm spinal canal mass at the L4-S1 level. Consequently, a laminectomy was performed at the L4-L5 level to remove the intramedullary tumor. Post-surgery histopathology and immunohistochemistry confirmed the tumor as ERWT with favorable histology without any teratomatous component.
CONCLUSION
CONCLUSIONS
This report underscores the rarity of extrarenal Wilms tumor (ERWT) in adults, challenging conventional assumptions about its typical age of occurrence. It emphasizes the importance of clinical awareness regarding such uncommon cases. Moreover, the co-occurrence of spinal ERWTs and a history of spinal anomalies warrants further investigation.
Identifiants
pubmed: 38858693
doi: 10.1186/s12894-024-01508-6
pii: 10.1186/s12894-024-01508-6
doi:
Types de publication
Journal Article
Case Reports
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119Informations de copyright
© 2024. The Author(s).
Références
Mitry E, Ciccolallo L, Coleman MP, Gatta G, Pritchard-Jones K, EUROCARE Working Group. Incidence of and survival from Wilms’ tumour in adults in Europe: data from the EUROCARE study. Eur J Cancer Oxf Engl 1990. 2006;42(14):2363–8.
Armanda V, Culić S, Pogorelić Z, Kuljiš D, Budimir D, Kuzmić-Prusac I. Rare localization of extrarenal nephroblastoma in 1-month-old female infant. J Pediatr Urol. 2012;8(4):e43–45.
doi: 10.1016/j.jpurol.2012.03.005
pubmed: 22465824
Steelman CK, Bannister LL, Palmer M, Chang TS, Elawabdeh N, Shehata BM. Nephrogenic rest within a lipomyelomeningocele in a patient with unilateral renal agenesis. Fetal Pediatr Pathol. 2012;31(4):260–4.
doi: 10.3109/15513815.2012.659377
pubmed: 22432683
Wu Y, Zhu X, Wang X, Wang H, Cao X, Wang J. Extrarenal nephroblastomatosis in children: a report of two cases. BMC Pediatr. 2014;14(1):255.
doi: 10.1186/1471-2431-14-255
pubmed: 25288411
pmcid: 4287104
Kartsanis G, Douros K, Ravazoula P, Fokaefs E. Adult Wilms’ tumor: a case report and review of literature. Int Urol Nephrol. 2007;39(1):3–6.
doi: 10.1007/s11255-006-0029-y
pubmed: 17268906
Sereke SG, Sahal AO, Mboizi V, Bongomin F. Synchronous bilateral Wilms’ tumor with liver metastasis. BMC Urol. 2021;21(1):91.
doi: 10.1186/s12894-021-00859-8
pubmed: 34112148
pmcid: 8193872
Moyson F, Maurus-Desmarez R, Gompel C. [Mediastinal Wilms’ tumor?]. Acta Chir Belg. 1961;Suppl 2:118–28.
pubmed: 14476767
Kaur N, Gupta A, Attam A, Shrivastava UK, Wadhwa N. Adult Wilms’ tumor: management considerations. Int Urol Nephrol. 2005;37(1):17–20.
doi: 10.1007/s11255-004-4696-2
pubmed: 16132751
Rehder P, Rehwald R, Böhm JM, Grams AE, Loizides A, Pedrini M, et al. Supernumerary kidneys: a clinical and radiological analysis of nine cases. BMC Urol. 2019;19(1):93.
doi: 10.1186/s12894-019-0522-0
pubmed: 31623590
pmcid: 6798430
Park J. Extrarenal retroperitoneal wilms’ tumor with subsequent pulmonary and peritoneal metastasis in a 4 year-old girl: a case report and review of literature. J Pediatr Surg Case Rep. 2016;8:19–21.
doi: 10.1016/j.epsc.2016.03.007
Guo F, Li T, Liu W, Wang G, Ma R, Wu R. Wilms tumor with inferior vena cava duplication: a rare case report. BMC Urol. 2018;18(1):88.
doi: 10.1186/s12894-018-0401-0
pubmed: 30340580
pmcid: 6194641
Oner UU, Tokar B, Açikalin MF, Ilhan H, Tel N. Wilms’ tumor of the ovary: a case report. J Pediatr Surg. 2002;37(1):127–9.
doi: 10.1053/jpsu.2002.29447
Huszno J, Starzyczny–Słota D, Jaworska M, Nowara E. Adult Wilms’ tumor – diagnosis and current therapy. Cent Eur J Urol. 2013;66(1):39–44.
doi: 10.5173/ceju.2013.01.art12
Leslie SW, Sajjad H, Murphy PB. Wilms Tumor. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Nov 19]. http://www.ncbi.nlm.nih.gov/books/NBK442004/ .
Horenstein MG, Manci EA, Walker AB, Dehner LP. Lumbosacral ectopic nephrogenic rest unassociated with spinal dysraphism. Am J Surg Pathol. 2004;28(10):1389–92.
doi: 10.1097/01.pas.0000131557.49774.29
pubmed: 15371957
Igbaseimokumo U, Cartwright C, Lewing K, Hutchison L, Habeebu S. The Rare Association of Spina Bifida and Extrarenal Wilms Tumor: a Case Report and Review of the literature. World Neurosurg. 2017;104:e10461–5.
doi: 10.1016/j.wneu.2017.03.115
Al-Nsoor N, Al-Emam O, Khader M. Extrarenal Wilms’ Tumor with Intraspinal Extension: a Case Report. J R Med Serv. 2014;21(3):71–4.
Taguchi S, Shono T, Mori D, Horie H. Extrarenal Wilms tumor in children with unfavorable histology: a case report. J Pediatr Surg. 2010;45(9):e19–22.
doi: 10.1016/j.jpedsurg.2010.06.004
pubmed: 20850611
Cooke A, Deshpande AV, La Hei ER, Kellie S, Arbuckle S, Cummins G. Ectopic nephrogenic rests in children: the clinicosurgical implications. J Pediatr Surg. 2009;44(12):e13–16.
doi: 10.1016/j.jpedsurg.2009.09.015
pubmed: 20005996
Shojaeian R, Hiradfar M, Sharifabad PS, Zabolinejad N. Extrarenal Wilms’ Tumor: Challenges in Diagnosis, Embryology, Treatment and Prognosis. In: van den Heuvel-Eibrink MM, editor. Wilms Tumor [Internet]. Brisbane (AU): Codon Publications; 2016 [cited 2023 Nov 19]. http://www.ncbi.nlm.nih.gov/books/NBK373353/ .
Zaresharifi N, Abbaspour E, Yousefzade-Chabok S, Reihanian Z, Karimian P, Karimzadhagh S. Rare incidence of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma: a case report and review of the literature. Int J Surg Case Rep. 2024;115:109322.
doi: 10.1016/j.ijscr.2024.109322
pubmed: 38281381
pmcid: 10839255
Alijani B, Karimzadhagh S, Abbaspour E, Reihanian Z, Haghani Dogahe M, Zaresharifi N. Intradural intramedullary epidermoid cyst in a 17-year-old male: an exceptionally rare case report and review of the literature. Int J Surg Case Rep. 2024;116:109331.
doi: 10.1016/j.ijscr.2024.109331
pubmed: 38340621
pmcid: 10943664
Zaresharifi N, Karimzadhagh S, Ebrahimian R, Reihanian Z, Abbaspour E, Karimian P, et al. Successful management of a giant retroperitoneal ancient schwannoma mimicking malignant tumors: a case report and literature review. Ann Med Surg 2012. 2023;85(12):6279–84.
doi: 10.1097/MS9.0000000000001445
Vallejo Yepes C, Bermudez M, Camacho-Nieto D, Mesa J, Bruges R. Adult Wilms’ Tumor: Case Report and Literature Review. Cureus 13(6):e15524.
Geethamani V, Kusuma V, Gowda KS, Saini ML. Adult Wilms’ tumour: a case report with review of literature. Diagn Pathol. 2006;1:46.
doi: 10.1186/1746-1596-1-46
pubmed: 17144931
pmcid: 1702367
Beech BB, Carlock HR, Rudzinski JK, Martinez DR, Dhillon J, Spiess PE. Extrarenal adult Wilms’ tumor case report. AME Med J [Internet]. 2019 Nov 26 [cited 2023 Nov 19];4(0). https://amj.amegroups.org/article/view/5250 .
Karim A, Shaikhyzada K, Abulkhanova N, Altyn A, Ibraimov B, Nurgaliyev D, et al. Pediatric Extra-renal Nephroblastoma (Wilms’ Tumor): a systematic case-based review. Cancers. 2023;15(9):2563.
doi: 10.3390/cancers15092563
pubmed: 37174029
pmcid: 10177564
Tokuç AG, Eker N, Tufan Taş B, Uyar Bozkurt S, Sakar M, Aras S, et al. An Astonishing Extrarenal Wilms localisation; spinal cord. J Pediatr Res. 2022;9(2):188–91.
doi: 10.4274/jpr.galenos.2021.34445
Sharma MC, Jain D, Sarkar C, Bhatnagar V, Rishi A, Suri V, et al. Lumbosacral Wilms’ tumor as a component of immature teratoma associated with spinal dysraphism–a rare case and short literature review. Fetal Pediatr Pathol. 2009;28(5):201–8.
doi: 10.1080/15513810903070654
pubmed: 19842874
Deshpande AV, Gawali JS, Sanghani HH, Shenoy AS, Patankar JZ, Borwankar SS. Extrarenal Wilm’s tumour - a rare entity. Pediatr Surg Int. 2002;18(5–6):543–4.
pubmed: 12415407
Govender D, Hadley GP, Nadvi SS, Donnellan RB. Primary lumbosacral Wilms tumour associated with occult spinal dysraphism. Virchows Arch Int J Pathol. 2000;436(5):502–5.
doi: 10.1007/s004280050480
Fahner JB, Switzer R, Freyer DR, Mann JD, Mann RJ. Extrarenal Wilms’ tumor. Unusual presentation in the lumbosacral region. Am J Pediatr Hematol Oncol. 1993;15(1):117–9.
doi: 10.1097/00043426-199302000-00018
pubmed: 8383474
Mirkin LD, Azzarelli B, Seo IS. Extrarenal Wilms’ Tumor with cerebellar metastasis in a four-year-old girl with Spina Bifida. Am J Clin Pathol. 1990;93(6):805–9.
doi: 10.1093/ajcp/93.6.805
pubmed: 2161181
Fernbach SK, Naidich TP, McLone DG, Leestma JE. Computed tomography of primary intrathecal Wilms tumor with diastematomyelia. J Comput Assist Tomogr. 1984;8(3):523–8.
doi: 10.1097/00004728-198406000-00029
pubmed: 6327789