Spatiotemporal expression and control of haemoglobin in space.

Humans Hemoglobins / metabolism Space Flight Gene Expression Regulation Erythropoiesis / genetics Gene Expression Profiling / methods

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
11 Jun 2024

Historique:

received: 19 06 2023

accepted: 31 05 2024

medline: 12 6 2024

pubmed: 12 6 2024

entrez: 11 6 2024

Statut: epublish

Résumé

It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homoeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production. Haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic datasets available on NASA GeneLab, from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research.

Identifiants

DOI: 10.1038/s41467-024-49289-8 PMID: 38862545

pubmed: 38862545

doi: 10.1038/s41467-024-49289-8

pii: 10.1038/s41467-024-49289-8

doi:

Substances chimiques

Hemoglobins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

4927

Informations de copyright

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