Assessing the perioperative gain of weight (Δweight) as a determinant of morbidity after kidney transplantation: a retrospective exploratory study.

Humans Kidney Transplantation / adverse effects Female Male Retrospective Studies Middle Aged Postoperative Complications / etiology Weight Gain Adult Perioperative Period Risk Factors Aged
Biomarkers Complications Outcomes Prediction Transplant

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 Jun 2024
Historique:
received: 26 03 2024
accepted: 03 06 2024
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 11 6 2024
Statut: epublish

Résumé

Kidney transplantation (KT) is associated with a substantial risk of postoperative complications (POC) for which performant predictors are lacking. Data showed that a perioperative gain of weight (ΔWeight) was associated with higher risk of POC, but it remains unexplored in KT. This retrospective study aimed to investigate the association between ΔWeight and POC after KT. ΔWeight was calculated on postoperative day (POD) 2. POC were graded according to the Dindo-Clavien classification. Primary endpoint was overall POC. A total of 242 patients were included and 174 (71.9%) complications were reported. Patients showed a rapid gain of weight after KT. Mean ΔWeight was 7.83 kg (± 3.20) compared to 5.3 kg (± 3.56) in patients with and without complication, respectively (p = 0.0005). ΔWeight showed an accuracy of 0.74 for overall POC. A cut-off of 8.5 kg was determined. ΔWeight ≥ 8.5 kg was identified as an independent predictor of overall POC on multivariable analysis (OR 2.04; 95% CI 1.08-3.84; p = 0.025). ΔWeight ≥ 8.5 kg appeared as an independent predictor of POC after KT. These results stress the need to monitor weight in KT and to further investigate this surrogate with future studies assessing its clinical relevance.

Identifiants

DOI: 10.1038/s41598-024-63950-8 PMID: 38862590
pubmed: 38862590
doi: 10.1038/s41598-024-63950-8
pii: 10.1038/s41598-024-63950-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13384

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Beatriz Barberá Carbonell (BB)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.

Tobias Zingg (T)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.

Maurice Matter (M)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.

Gaëtan-Romain Joliat (GR)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.
Graduate School of Health Sciences, University of Bern, Bern, Switzerland.

David Martin (D)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.

Manuel Pascual (M)

Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.
Transplantation Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Nicolas Demartines (N)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.

Dela Golshayan (D)

Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland.
Transplantation Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Luis Cano (L)

Nutrition Metabolism and Cancer, INSERM, University of Rennes, INRAE, CHU Pontchaillou, UMR 1241 NUMECAN, Rennes, France.

Ismail Labgaa (I)

Department of Visceral Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland. ismail.labgaa@chuv.ch.
Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland. ismail.labgaa@chuv.ch.
ORCID: 0000-0003-4286-2170

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