An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein.
Alkb dioxygenases
N6-methyladenosine
NMR
liquid chromatography–mass spectrometry
molecular dynamics simulations
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 Jun 2024
18 Jun 2024
Historique:
medline:
12
6
2024
pubmed:
12
6
2024
entrez:
12
6
2024
Statut:
ppublish
Résumé
The fat mass and obesity-associated fatso (FTO) protein is a member of the Alkb family of dioxygenases and catalyzes oxidative demethylation of N
Identifiants
pubmed: 38865275
doi: 10.1073/pnas.2404457121
doi:
Substances chimiques
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
EC 1.14.11.33
FTO protein, human
EC 1.14.11.33
Ketoglutaric Acids
0
Iron
E1UOL152H7
Adenosine
K72T3FS567
3-methylthymine
SS2K4WB6YL
N-methyladenosine
CLE6G00625
3-methyluracil
608-34-4
Uracil
56HH86ZVCT
Thymine
QR26YLT7LT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2404457121Subventions
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM133488
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM138243
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.