Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.

Animals Graft Survival / immunology Humans Transplantation, Heterologous Animals, Genetically Modified Swine Galactosyltransferases / genetics Graft Rejection / immunology Transgenes Gene Knockout Techniques Macaca mulatta Kidney Transplantation

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
12 Jun 2024
Historique:
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 12 6 2024
Statut: ppublish

Résumé

Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially benefit the most from the clinical implementation of xenotransplantation. Here, five highly allosensitized rhesus macaques received a porcine kidney from

Identifiants

DOI: 10.1126/scitranslmed.adk6152 PMID: 38865482
pubmed: 38865482
doi: 10.1126/scitranslmed.adk6152
doi:

Substances chimiques

Galactosyltransferases EC 2.4.1.-
alpha-1,3-galactosyltransferase 1, porcine EC 2.4.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadk6152

Auteurs

Miriam Manook (M)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-6474-6122

Danae Olaso (D)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-2070-6022

Imran Anwar (I)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-5075-4148

Isabel DeLaura (I)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-2340-0918

Janghoon Yoon (J)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0001-8543-194X

Yeeun Bae (Y)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-0485-5036

Andrew Barbas (A)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0003-3476-2313

Brian Shaw (B)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-2317-6549

Dimitrios Moris (D)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.

Mingqing Song (M)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-2462-9351

Alton B Farris (AB)

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
ORCID: 0000-0001-5534-7763

Kathryn Stiede (K)

eGenesis Inc, Cambridge, MA 02140, USA.
ORCID: 0000-0002-0605-0581

Michele Youd (M)

eGenesis Inc, Cambridge, MA 02140, USA.
ORCID: 0009-0001-4677-9115

Stuart Knechtle (S)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-1625-385X

Jean Kwun (J)

Duke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.
ORCID: 0000-0002-8563-5472

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation hétérologue › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Galactosyltransferases › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Transgènes › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Prolonged xenokidney graft survival in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Transplantation rénale › Prolonged xenokidney graft survival in...