Enhancing the yield of Xenocoumacin 1 in Xenorhabdus nematophila YL001 by optimizing the fermentation process.
Xenorhabdus nematophila
Biopesticide
Fermentation optimization
Response surface methodology
Xenocoumacin 1 (Xcn1)
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 06 2024
12 06 2024
Historique:
received:
10
01
2024
accepted:
03
06
2024
medline:
13
6
2024
pubmed:
13
6
2024
entrez:
12
6
2024
Statut:
epublish
Résumé
Xenocoumacin 1 (Xcn 1), antibiotic discovered from secondary metabolites of Xenorhabdus nematophila, had the potential to develop into a new pesticide due to its excellent activity against bacteria, oomycetes and fungi. However, the current low yield of Xcn1 limits its development and utilization. To improve the yield of Xcn1, response surface methodology was used to determine the optimal composition of fermentation medium and one factor at a time approach was utilized to optimize the fermentation process. The optimal medium composed of in g/L: proteose peptone 20.8; maltose 12.74; K
Identifiants
pubmed: 38866882
doi: 10.1038/s41598-024-63794-2
pii: 10.1038/s41598-024-63794-2
doi:
Substances chimiques
Culture Media
0
xenocoumacin 1
105688-01-5
Anti-Bacterial Agents
0
Benzopyrans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13506Subventions
Organisme : National Natural Science Foundation of China
ID : 32072474
Informations de copyright
© 2024. The Author(s).
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