Tailoring silk fibroin hydrophilicity and physicochemical properties using sugar alcohols for medical device coatings.
Hydrophilic coating
Molecular docking
Silk fibroin
Sugar alcohol
Water contact angle
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 Jun 2024
14 Jun 2024
Historique:
received:
16
02
2024
accepted:
10
06
2024
medline:
15
6
2024
pubmed:
15
6
2024
entrez:
14
6
2024
Statut:
epublish
Résumé
This study explores the modification of silk fibroin films for hydrophilic coating applications using various sugar alcohols. Films, prepared via solvent casting, incorporated glycerol, sorbitol, and maltitol, revealing distinctive transparency and UV absorption characteristics based on sugar alcohol chemical structures. X-ray diffraction confirmed a silk I to silk II transition influenced by sugar alcohols. Glycerol proved most effective in enhancing the β-sheet structure. The study also elucidated a conformational shift towards a β-sheet structure induced by sugar alcohols. Silk fibroin-sugar alcohol blind docking and sugar alcohol-sugar alcohol blind docking investigations were conducted utilizing the HDOCK Server. The computer simulation unveiled the significance of size and hydrogen bonding characteristics inherent in sugar alcohols, emphasizing their pivotal role in influencing interactions within silk fibroin matrices. Hydrophilicity of ozonized silicone surfaces improved through successful coating with silk fibroin films, particularly glycerol-containing ones, resulting in reduced contact angles. Strong adhesion between silk fibroin films and ozonized silicone surfaces was evident, indicating robust hydrogen bonding interactions. This comprehensive research provides crucial insights into sugar alcohols' potential to modify silk fibroin film crystalline structures, offering valuable guidance for optimizing their design and functionality, especially in silicone coating applications.
Identifiants
pubmed: 38877138
doi: 10.1038/s41598-024-64450-5
pii: 10.1038/s41598-024-64450-5
doi:
Substances chimiques
Fibroins
9007-76-5
Sugar Alcohols
0
Coated Materials, Biocompatible
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13781Subventions
Organisme : Faculty of Science, Burapha University, Thailand
ID : SIF-IN-64910181
Organisme : Faculty of Science, Burapha University, Thailand
ID : SIF-IN-64910181
Informations de copyright
© 2024. The Author(s).
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