A new pharmacological approach for tracheal intubation?

Humans Intubation, Intratracheal / methods Rocuronium / administration & dosage Neuromuscular Nondepolarizing Agents / antagonists & inhibitors Sugammadex / pharmacology Androstanols / antagonists & inhibitors Benzodiazepines / pharmacology Fentanyl Analgesics, Opioid Naloxone Rapid Sequence Induction and Intubation / methods
flumazenil naloxone neuromuscular block rapid sequence induction remimazolam reversal rocuronium sugammadex

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
Jul 2024
Historique:
received: 03 04 2024
revised: 05 04 2024
accepted: 06 04 2024
medline: 16 6 2024
pubmed: 16 6 2024
entrez: 15 6 2024
Statut: ppublish

Résumé

Anaesthesia induced with remimazolam and a fentanyl-series opioid can be reversed with flumazenil and naloxone. Concomitant paralysis with rocuronium can facilitate tracheal intubation whilst being reversible with sugammadex. Together, this combination might offer full reversibility of a 'routine' or a 'rapid-sequence' induction anaesthesia. Whether this is useful, or even safe, requires careful evaluation.

Identifiants

DOI: 10.1016/j.bja.2024.04.005 PMID: 38879265
pubmed: 38879265
pii: S0007-0912(24)00200-9
doi: 10.1016/j.bja.2024.04.005
pii:
doi:

Substances chimiques

Rocuronium WRE554RFEZ
Neuromuscular Nondepolarizing Agents 0
Sugammadex 361LPM2T56
Androstanols 0
remimazolam 7V4A8U16MB
Benzodiazepines 12794-10-4
Fentanyl UF599785JZ
Analgesics, Opioid 0
Naloxone 36B82AMQ7N

Types de publication

Journal Article Editorial

Langues

eng

Sous-ensembles de citation

IM

Pagination

16-18

Informations de copyright

Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Auteurs

J Robert Sneyd (JR)

Faculty of Medicine and Dentistry, University of Plymouth, John Bull Building, Plymouth Science Park, Plymouth, UK. Electronic address: robert.sneyd@pms.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Techniques d'investigation › Intubation › Intubation trachéale › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Androstanes › Androstanols › Rocuronium › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents du système nerveux périphérique › Agents neuromusculaires › Curarisants › Curarisants non dépolarisants › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Amidon › Dextrine › Cyclodextrines › Cyclodextrines gamma › Sugammadex › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Androstanes › Androstanols › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Fentanyl › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Naloxone › A new pharmacological approach for tracheal intubation?
questionsmedicales.fr › Techniques d'investigation › Intubation › Intubation trachéale › Induction en séquence rapide avec intubation › A new pharmacological approach for tracheal intubation?