The single-cell opioid responses in the context of HIV (SCORCH) consortium.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
15 Jun 2024
Historique:
received: 05 11 2023
accepted: 17 05 2024
revised: 12 05 2024
medline: 16 6 2024
pubmed: 16 6 2024
entrez: 15 6 2024
Statut: aheadofprint

Résumé

Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of the seminal challenges in treating and studying addiction in human populations is the high prevalence of co-morbid conditions, including an increased risk of contracting a human immunodeficiency virus (HIV) infection. Of the ~15 million people who inject drugs globally, 17% are persons with HIV. Conversely, HIV is a risk factor for SUD because chronic pain syndromes, often encountered in persons with HIV, can lead to an increased use of opioid pain medications that in turn can increase the risk for opioid addiction. We hypothesize that SUD and HIV exert shared effects on brain cell types, including adaptations related to neuroplasticity, neurodegeneration, and neuroinflammation. Basic research is needed to refine our understanding of these affected cell types and adaptations. Studying the effects of SUD in the context of HIV at the single-cell level represents a compelling strategy to understand the reciprocal interactions among both conditions, made feasible by the availability of large, extensively-phenotyped human brain tissue collections that have been amassed by the Neuro-HIV research community. In addition, sophisticated animal models that have been developed for both conditions provide a means to precisely evaluate specific exposures and stages of disease. We propose that single-cell genomics is a uniquely powerful technology to characterize the effects of SUD and HIV in the brain, integrating data from human cohorts and animal models. We have formed the Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium to carry out this strategy.

Identifiants

pubmed: 38879719
doi: 10.1038/s41380-024-02620-7
pii: 10.1038/s41380-024-02620-7
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDA NIH HHS
ID : UM1 DA052244
Pays : United States

Informations de copyright

© 2024. The Author(s).

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Auteurs

Seth A Ament (SA)

University of Maryland School of Medicine, Baltimore, MD, USA. sament@som.umaryland.edu.

Rianne R Campbell (RR)

University of Maryland School of Medicine, Baltimore, MD, USA.

Mary Kay Lobo (MK)

University of Maryland School of Medicine, Baltimore, MD, USA.

Joseph P Receveur (JP)

University of Maryland School of Medicine, Baltimore, MD, USA.

Kriti Agrawal (K)

Yale School of Medicine, New Haven, CT, USA.

Alejandra Borjabad (A)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Siddappa N Byrareddy (SN)

University of Nebraska Medical Center, Omaha, NE, USA.

Linda Chang (L)

University of Maryland School of Medicine, Baltimore, MD, USA.

Declan Clarke (D)

Yale School of Medicine, New Haven, CT, USA.

Prashant Emani (P)

Yale School of Medicine, New Haven, CT, USA.

Dana Gabuzda (D)

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Kyle J Gaulton (KJ)

University of California San Diego, La Jolla, CA, USA.

Michelle Giglio (M)

University of Maryland School of Medicine, Baltimore, MD, USA.

Federico M Giorgi (FM)

University of Bologna, Bologna, Italy.

Busra Gok (B)

Boston University, Boston, MA, USA.

Chittibabu Guda (C)

University of Nebraska Medical Center, Omaha, NE, USA.

Eran Hadas (E)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Brian R Herb (BR)

University of Maryland School of Medicine, Baltimore, MD, USA.

Wen Hu (W)

Weill Cornell Medicine, New York, NY, USA.

Anita Huttner (A)

Yale School of Medicine, New Haven, CT, USA.

Mohammad R Ishmam (MR)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Michelle M Jacobs (MM)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Jennifer Kelschenbach (J)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Dong-Wook Kim (DW)

Allen Institute for Brain Science, Seattle, WA, USA.

Cheyu Lee (C)

University of California Irvine, Irvine, CA, USA.

Shuhui Liu (S)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Xiaokun Liu (X)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bertha K Madras (BK)

McLean Hospital, Harvard Medical School, Belmont, MA, USA.

Anup A Mahurkar (AA)

University of Maryland School of Medicine, Baltimore, MD, USA.

Deborah C Mash (DC)

University of Miami, Miami, FL, USA.

Eran A Mukamel (EA)

University of California San Diego, La Jolla, CA, USA.

Meng Niu (M)

University of Nebraska Medical Center, Omaha, NE, USA.

Richard M O'Connor (RM)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Chelsea M Pagan (CM)

Allen Institute for Brain Science, Seattle, WA, USA.

Alina P S Pang (APS)

Weill Cornell Medicine, New York, NY, USA.

Piya Pillai (P)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Vez Repunte-Canonigo (V)

The Scripps Research Institute, La Jolla, CA, USA.

W Brad Ruzicka (WB)

McLean Hospital, Harvard Medical School, Belmont, MA, USA.

Jay Stanley (J)

Yale School of Medicine, New Haven, CT, USA.

Timothy Tickle (T)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Shang-Yi A Tsai (SA)

National Institute on Drug Abuse, Bethesda, MD, USA.

Allen Wang (A)

University of California San Diego, La Jolla, CA, USA.

Lauren Wills (L)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Alyssa M Wilson (AM)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Susan N Wright (SN)

National Institute on Drug Abuse, Bethesda, MD, USA.

Siwei Xu (S)

University of California Irvine, Irvine, CA, USA.

Junchen Yang (J)

Yale School of Medicine, New Haven, CT, USA.

Maryam Zand (M)

University of California San Diego, La Jolla, CA, USA.

Le Zhang (L)

Yale School of Medicine, New Haven, CT, USA.

Jing Zhang (J)

University of California Irvine, Irvine, CA, USA.

Schahram Akbarian (S)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Shilpa Buch (S)

University of Nebraska Medical Center, Omaha, NE, USA.

Christine S Cheng (CS)

University of California San Diego, La Jolla, CA, USA.

Michael J Corley (MJ)

Weill Cornell Medicine, New York, NY, USA.

Howard S Fox (HS)

University of Nebraska Medical Center, Omaha, NE, USA.

Mark Gerstein (M)

Yale School of Medicine, New Haven, CT, USA.

Suryaram Gummuluru (S)

Boston University, Boston, MA, USA.

Myriam Heiman (M)

Massachusetts Institute of Technology, Cambridge, MA, USA.

Ya-Chi Ho (YC)

Yale School of Medicine, New Haven, CT, USA.

Manolis Kellis (M)

Massachusetts Institute of Technology, Cambridge, MA, USA.

Paul J Kenny (PJ)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Yuval Kluger (Y)

Yale School of Medicine, New Haven, CT, USA.

Teresa A Milner (TA)

Weill Cornell Medicine, New York, NY, USA.

David J Moore (DJ)

University of California San Diego, La Jolla, CA, USA.

Susan Morgello (S)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lishomwa C Ndhlovu (LC)

Weill Cornell Medicine, New York, NY, USA.

Tariq M Rana (TM)

University of California San Diego, La Jolla, CA, USA.

Pietro Paolo Sanna (PP)

The Scripps Research Institute, La Jolla, CA, USA.

John S Satterlee (JS)

National Institute on Drug Abuse, Bethesda, MD, USA.

Nenad Sestan (N)

Yale School of Medicine, New Haven, CT, USA.

Stephen A Spector (SA)

University of California San Diego, La Jolla, CA, USA.

Serena Spudich (S)

Yale School of Medicine, New Haven, CT, USA.

Hagen U Tilgner (HU)

Weill Cornell Medicine, New York, NY, USA.

David J Volsky (DJ)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Owen R White (OR)

University of Maryland School of Medicine, Baltimore, MD, USA.

Dionne W Williams (DW)

Emory University School of Medicine, Atlanta, GA, USA.

Hongkui Zeng (H)

Allen Institute for Brain Science, Seattle, WA, USA.

Classifications MeSH