Tissue gene expression profiles and communication networks inform candidate blood biomarker identification in psoriasis and atopic dermatitis.

Atopic dermatitis Bioinformatic Biomarker Inflammation Psoriasis Spatial transcriptomics Treatment

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
14 Jun 2024
Historique:
received: 18 02 2024
revised: 24 05 2024
accepted: 10 06 2024
medline: 17 6 2024
pubmed: 17 6 2024
entrez: 16 6 2024
Statut: aheadofprint

Résumé

Overlapping clinical and pathomechanistic features can complicate the diagnosis and treatment of inflammatory skin diseases, including psoriasis and atopic dermatitis (AD). Spatial transcriptomics allows the identification of disease- and cell-specific molecular signatures that may advance biomarker development and future treatments. This study identified transcriptional signatures in keratinocytes and sub-basal CD4

Identifiants

DOI: 10.1016/j.clim.2024.110283 PMID: 38880200
pubmed: 38880200
pii: S1521-6616(24)00392-9
doi: 10.1016/j.clim.2024.110283
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110283

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest C.M.H. received unrestricted research funding from Novartis (psoriasis) and participated in advisory boards organized by Novartis (CNO/CRMO). The other authors have no financial conflicts of interest.

Auteurs

J Soul (J)

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.

E Carlsson (E)

Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

S R Hofmann (SR)

Department of Pediatrics, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

S Russ (S)

Department of Pediatrics, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

J Hawkes (J)

Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

F Schulze (F)

Department of Pediatrics, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

M Sergon (M)

Institut of Pathology, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

J Pablik (J)

Institut of Pathology, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

S Abraham (S)

Department of Dermatology, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

C M Hedrich (CM)

Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, United Kingdom. Electronic address: christian.hedrich@liverpool.ac.uk.

Classifications MeSH