Longitudinal study of the role of salivary proteins on radiation-related caries onset in head and neck cancer patients using 5000 ppm fluoride dentifrice up to one-year post-intensity modulated radiotherapy.
Humans
Dental Caries
/ prevention & control
Male
Salivary Proteins and Peptides
Head and Neck Neoplasms
/ radiotherapy
Female
Middle Aged
Longitudinal Studies
Radiotherapy, Intensity-Modulated
Dentifrices
/ therapeutic use
Aged
Fluorides
/ therapeutic use
Adult
DMF Index
Immunoglobulin A
/ analysis
Saliva
/ metabolism
Head and neck cancer
Immunoglobulin A
Radiation caries
Saliva
Salivary proteins and peptides
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
18 Jun 2024
18 Jun 2024
Historique:
received:
01
04
2024
accepted:
12
06
2024
medline:
18
6
2024
pubmed:
18
6
2024
entrez:
17
6
2024
Statut:
epublish
Résumé
Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients(HNC) up to one-year post-IMRT using a 5000ppm fluoride paste daily. Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT, six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT/salivary parameters were quantified, including flow rate, mucin 5B/7, Immunoglobulin A (IgA), cystatin S and α-amylase. 45% patients had at least one carious lesion at T2, a significant reduction in the number of remaining teeth (65% <21), salivary flow rate (< 50%) and, protein secretion (< 0.05) post-IMRT. T1 IgA concentration/secretion rate was associated with RC (p < 0.05). Finally, IgA and total protein concentration obtained at T1 could provide a predictive pattern (AUC 82.3%) for the patients more predisposed to developing RC at T2. This study demonstrated the significant association of RC with salivary proteins in HNC patients treated with IMRT, revealing the potential role of salivary proteins in the early diagnosis of RC. This research contributes to revealing salivary proteins association with RC, and its role in early diagnosis. Therefore, this could be the first step towards personalized medicine approaches to improve this group quality-of-life.
Identifiants
pubmed: 38886263
doi: 10.1007/s00784-024-05788-y
pii: 10.1007/s00784-024-05788-y
doi:
Substances chimiques
Salivary Proteins and Peptides
0
Dentifrices
0
Fluorides
Q80VPU408O
Immunoglobulin A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379Subventions
Organisme : Agencia Nacional de Investigación y Desarrollo
ID : 6694/201
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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