Comparison of juvenile and adult myasthenia gravis in a French cohort with focus on thymic histology.
Age
Autoimmunity
Follicular hyperplasia
Puberty
Thymectomy
Thymus
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 06 2024
17 06 2024
Historique:
received:
02
02
2024
accepted:
26
05
2024
medline:
18
6
2024
pubmed:
18
6
2024
entrez:
17
6
2024
Statut:
epublish
Résumé
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle fatigability due to acetylcholine receptor (AChR) autoantibodies. To better characterize juvenile MG (JMG), we analyzed 85 pre- and 132 post-pubescent JMG (with a cutoff age of 13) compared to 721 adult MG patients under 40 years old using a French database. Clinical data, anti-AChR antibody titers, thymectomy, and thymic histology were analyzed. The proportion of females was higher in each subgroup. No significant difference in the anti-AChR titers was observed. Interestingly, the proportion of AChR
Identifiants
pubmed: 38886398
doi: 10.1038/s41598-024-63162-0
pii: 10.1038/s41598-024-63162-0
doi:
Substances chimiques
Autoantibodies
0
Receptors, Cholinergic
0
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
13955Subventions
Organisme : FP7 Health
ID : FIGHT-MG/HEALTH-2009-242-210
Organisme : FP7 Health
ID : FIGHT-MG/HEALTH-2009-242-210
Organisme : European Commission
ID : MYASTAID/LSHM-CT-2006-037833
Informations de copyright
© 2024. The Author(s).
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