Marine-Derived Phosphoeleganin and Its Semisynthetic Derivative Decrease IL6 Levels and Improve Insulin Signaling in Human Hepatocellular Carcinoma Cells.
Humans
Interleukin-6
/ metabolism
Insulin
/ metabolism
Liver Neoplasms
/ metabolism
Carcinoma, Hepatocellular
/ metabolism
Signal Transduction
/ drug effects
Hep G2 Cells
Animals
Receptor, Insulin
/ metabolism
Phosphorylation
/ drug effects
Proto-Oncogene Proteins c-akt
/ metabolism
Insulin Resistance
Antigens, CD
HepG2 cells
cytokines
insulin signaling
marine natural products
phosphoeleganin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 May 2024
30 May 2024
Historique:
received:
19
04
2024
revised:
24
05
2024
accepted:
29
05
2024
medline:
19
6
2024
pubmed:
19
6
2024
entrez:
19
6
2024
Statut:
epublish
Résumé
Marine natural products constitute a great source of potential new antidiabetic drugs. The aim of this study was to evaluate the role of phosphoeleganin (PE), a polyketide purified from the Mediterranean ascidian
Identifiants
pubmed: 38892230
pii: ijms25116039
doi: 10.3390/ijms25116039
pii:
doi:
Substances chimiques
Interleukin-6
0
Insulin
0
Receptor, Insulin
EC 2.7.10.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
IL6 protein, human
0
INSR protein, human
EC 2.7.10.1
Antigens, CD
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Universities and Research
ID : PRIN 2022 PNRR: P2022PPH4C