Phenethylamines / pharmacology Humans Receptors, G-Protein-Coupled / metabolism Dietary Supplements Receptors, Adrenergic / metabolism HEK293 Cells
adrenaline adrenergic receptors alkylamine analogues food supplements phenethylamine analogues trace amine-associated receptor 1

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
22 May 2024
Historique:
received: 12 04 2024
revised: 15 05 2024
accepted: 16 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

Pre-workout supplements are popular among sport athletes and overweight individuals. Phenethylamines (PEAs) and alkylamines (AA) are widely present in these supplements. Although the health effects of these analogues are not well understood yet, they are hypothesised to be agonists of adrenergic (ADR) and trace amine-associated receptors (TAARs). Therefore, we aimed to pharmacologically characterise these compounds by investigating their activating properties of ADRs and TAAR1

Identifiants

DOI: 10.3390/nu16111567 PMID: 38892500
pubmed: 38892500
pii: nu16111567
doi: 10.3390/nu16111567
pii:
doi:

Substances chimiques

Phenethylamines 0
Receptors, G-Protein-Coupled 0
Trace amine-associated receptor 1 XMC8VP6RI2
phenethylamine 327C7L2BXQ
Receptors, Adrenergic 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : The Dutch Ministry of Agriculture, Nature and Food Quality
ID : n.a.

Auteurs

Nicole E T Pinckaers (NET)

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
ORCID: 0009-0006-6879-5243

W Matthijs Blankesteijn (WM)

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.
School for Cardiovascular Diseases (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
ORCID: 0000-0002-4375-0907

Anastasiya Mircheva (A)

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.

Xiao Shi (X)

Research Service, Veterans Affairs Portland Health Care System, Portland, OR 97239, USA.
Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA.
ORCID: 0000-0002-6944-9135

Antoon Opperhuizen (A)

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Office for Risk Assessment and Research, Netherlands Food and Consumer Product Safety Authority, 3540 AA Utrecht, The Netherlands.

Frederik-Jan van Schooten (FV)

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6200 MD Maastricht, The Netherlands.

Misha F Vrolijk (MF)

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands.
Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
ORCID: 0000-0002-2751-8972

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Éthylamines › Phénéthylamines ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G ›
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs adrénergiques ›
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 ›