In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from
Molecular Docking Simulation
Cholinesterase Inhibitors
/ pharmacology
Hypoglycemic Agents
/ chemistry
Plant Extracts
/ chemistry
alpha-Amylases
/ antagonists & inhibitors
Acetylcholinesterase
/ metabolism
Terminalia
/ chemistry
Humans
Butyrylcholinesterase
/ metabolism
alpha-Glucosidases
/ metabolism
Glycoside Hydrolase Inhibitors
/ pharmacology
Molecular Structure
Alzheimer’s disease
Terminalia macroptera
cholinesterase inhibition
diabetes
molecular docking
α-amylase inhibition
α-glucosidase inhibition
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 May 2024
23 May 2024
Historique:
received:
19
04
2024
revised:
17
05
2024
accepted:
19
05
2024
medline:
19
6
2024
pubmed:
19
6
2024
entrez:
19
6
2024
Statut:
epublish
Résumé
Alzheimer's disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are suitable therapies for AD, while α-amylase and α-glucosidase inhibitors are employed as antidiabetic agents. Compounds were isolated from the medicinal plant
Identifiants
pubmed: 38893333
pii: molecules29112456
doi: 10.3390/molecules29112456
pii:
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Hypoglycemic Agents
0
Plant Extracts
0
alpha-Amylases
EC 3.2.1.1
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
alpha-Glucosidases
EC 3.2.1.20
Glycoside Hydrolase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM