2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives.

Humans Structure-Activity Relationship Purinergic P1 Receptor Antagonists / pharmacology Receptors, Purinergic P1 / metabolism Molecular Structure Adenine / analogs & derivatives Morpholines / chemistry Purines / chemistry CHO Cells
2-arylpurine derivatives G protein-coupled receptors adenine derivatives adenosine receptor antagonists structure-activity relationship

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
28 May 2024
Historique:
received: 08 02 2024
revised: 06 05 2024
accepted: 24 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A

Identifiants

DOI: 10.3390/molecules29112543 PMID: 38893418
pubmed: 38893418
pii: molecules29112543
doi: 10.3390/molecules29112543
pii:
doi:

Substances chimiques

Purinergic P1 Receptor Antagonists 0
Receptors, Purinergic P1 0
Adenine JAC85A2161
Morpholines 0
Purines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Fundação para a Ciência e Tecnologia
ID : UID/QUI/00686/2020, UID/QUI/ 00686/2018; SFRH/BD/22270/2005; SFRH/BD/85937/2012; SFRH/BPD/ 26106/2005
Organisme : FEDER funds through the Operational Programme for Competitiveness Factors (COMPETE 2020), Programa Operacional de Competitividade e Internacionalização (POCI)
ID : POCI-01-0145-FEDER-031354
Organisme : Rede Nacional de RMN
ID : PINFRA/22161/2016
Organisme : Xunta de Galicia
ID : ED431C 2022/20
Organisme : European Regional Development Fund
ID : ERDF

Auteurs

Filipe Areias (F)

Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.
School of Chemical Sciences & Engineering, Yachay Tech University, Yachay City of Knowledge, Urcuqui 100119, Ecuador.

Carla Correia (C)

Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.

Ashly Rocha (A)

Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.

Sofia Teixeira (S)

Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
ORCID: 0000-0002-4086-0975

Marián Castro (M)

Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, E-15706 Santiago de Compostela, Spain.
ORCID: 0000-0002-4732-1966

Jose Brea (J)

Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, E-15706 Santiago de Compostela, Spain.
ORCID: 0000-0002-5523-1979

Huabin Hu (H)

Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.

Jens Carlsson (J)

Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.
ORCID: 0000-0003-4623-2977

Maria I Loza (MI)

Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana s/n, E-15706 Santiago de Compostela, Spain.

M Fernanda Proença (MF)

Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
ORCID: 0000-0002-5274-1949

M Alice Carvalho (MA)

Centre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P1 › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adénine › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Morpholines › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › 2-Aryladenine Derivatives as a Potent Scaffold...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › 2-Aryladenine Derivatives as a Potent Scaffold...