The extracellular serine protease from
Humans
Staphylococcus epidermidis
/ immunology
Dermatitis, Atopic
/ immunology
Serine Proteases
/ immunology
Adult
Male
Female
Immunoglobulin E
/ immunology
Bacterial Proteins
/ immunology
Immunoglobulin G
/ immunology
Cytokines
/ metabolism
T-Lymphocytes
/ immunology
Allergens
/ immunology
Interleukin-33
/ immunology
Middle Aged
Esp
IgE
Staphylococcus epidermidis
Th2 cells
allergy
atopic dermatitis
protease
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
08
12
2023
accepted:
02
05
2024
medline:
19
6
2024
pubmed:
19
6
2024
entrez:
19
6
2024
Statut:
epublish
Résumé
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with skin barrier defects and a misdirected type 2 immune response against harmless antigens. The skin microbiome in AD is characterized by a reduction in microbial diversity with a dominance of staphylococci, including To assess whether To identify candidate allergens, we analyzed the binding of human serum IgG4, as a surrogate of IgE, to We identified Esp as the dominant candidate allergen of The extracellular serine protease Esp of
Sections du résumé
Background
UNASSIGNED
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with skin barrier defects and a misdirected type 2 immune response against harmless antigens. The skin microbiome in AD is characterized by a reduction in microbial diversity with a dominance of staphylococci, including
Objective
UNASSIGNED
To assess whether
Methods
UNASSIGNED
To identify candidate allergens, we analyzed the binding of human serum IgG4, as a surrogate of IgE, to
Results
UNASSIGNED
We identified Esp as the dominant candidate allergen of
Conclusion
UNASSIGNED
The extracellular serine protease Esp of
Identifiants
pubmed: 38895118
doi: 10.3389/fimmu.2024.1352704
pmc: PMC11183529
doi:
Substances chimiques
Serine Proteases
EC 3.4.-
Immunoglobulin E
37341-29-0
Bacterial Proteins
0
Immunoglobulin G
0
Cytokines
0
Allergens
0
Interleukin-33
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1352704Informations de copyright
Copyright © 2024 Abdurrahman, Pospich, Steil, Gesell Salazar, Izquierdo González, Normann, Mrochen, Scharf, Völker, Werfel, Bröker, Roesner and Gómez-Gascón.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.