Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial.
Chronobiology
Circadian rhythms
Home parenteral nutrition
Metabolomics
Nutrition
Journal
Clinical nutrition ESPEN
ISSN: 2405-4577
Titre abrégé: Clin Nutr ESPEN
Pays: England
ID NLM: 101654592
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
07
02
2024
revised:
16
04
2024
accepted:
29
04
2024
medline:
21
6
2024
pubmed:
21
6
2024
entrez:
20
6
2024
Statut:
ppublish
Résumé
Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight. This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis. Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m Daytime infusions of HPN may result in changes in circulating lipids and amino acid composing metabolic pathways previously implicated in circadian rhythms. As this is the first untargeted metabolomics study of HPN, larger studies are needed.
Sections du résumé
BACKGROUND
BACKGROUND
Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight.
METHODS
METHODS
This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis.
RESULTS
RESULTS
Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m
CONCLUSION
CONCLUSIONS
Daytime infusions of HPN may result in changes in circulating lipids and amino acid composing metabolic pathways previously implicated in circadian rhythms. As this is the first untargeted metabolomics study of HPN, larger studies are needed.
Identifiants
pubmed: 38901946
pii: S2405-4577(24)00120-7
doi: 10.1016/j.clnesp.2024.04.025
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT04743960']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-32Informations de copyright
Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest MFW is a scientific advisor for Takeda Pharmaceuticals (Lexington, MA) and VectivBio (Basel, Switzerland). HSD, MSG, KMM, and CC declare no competing interests. The content is solely the responsibility of the authors and does not necessarily represent the official views of funders.