Reduced graphene oxide/zinc oxide composite as an electrochemical sensor for acetylcholine detection.
Acetylcholine
Electrocatalytic activity
Reduced graphene oxide
Sensor
Zinc oxide
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 06 2024
20 06 2024
Historique:
received:
19
02
2024
accepted:
06
06
2024
medline:
21
6
2024
pubmed:
21
6
2024
entrez:
20
6
2024
Statut:
epublish
Résumé
Acetylcholine (ACh) plays a pivotal role as a neurotransmitter, influencing nerve cell communication and overall nervous system health. Imbalances in ACh levels are linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. This study focused on developing electrochemical sensors for ACh detection, utilizing graphene oxide (GO) and a composite of reduced graphene oxide and zinc oxide (rGO/ZnO). The synthesis involved modified Hummers' and hydrothermal methods, unveiling the formation of rGO through deoxygenation and the integration of nano-sized ZnO particles onto rGO, as demonstrated by XPS and TEM. EIS analysis also revealed the enhancement of electron transfer efficiency in rGO/ZnO. Cyclic voltammograms of the electrode, comprising the rGO/ZnO composite in ACh solutions, demonstrated prominent oxidation and reduction reactions. Notably, the composite exhibited promise for ACh detection due to its sensitivity, low detection threshold, reusability, and selectivity against interfering compounds, specifically glutamate and gamma-aminobutyric acid. The unique properties of rGO, such as high specific surface area and electron mobility, coupled with ZnO's stability and catalytic efficiency, contributed to the composite's potential in electrochemical sensor applications. This research, emphasizing the synthesis, fabrication, and characterization of the rGO/ZnO composite, established itself as a reliable platform for detecting the acetylcholine neurotransmitter.
Identifiants
pubmed: 38902301
doi: 10.1038/s41598-024-64238-7
pii: 10.1038/s41598-024-64238-7
doi:
Substances chimiques
Graphite
7782-42-5
Zinc Oxide
SOI2LOH54Z
Acetylcholine
N9YNS0M02X
graphene oxide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14224Subventions
Organisme : Kasetsart University Research and Development Institute
ID : FF(KU) 25.64
Informations de copyright
© 2024. The Author(s).
Références
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